Journal ArticleDOI
Gold nanoparticles as carriers for efficient transmucosal insulin delivery.
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TLDR
It is reported that there is a significant reduction of blood glucose levels (postprandial hyperglycemia) when insulin is delivered using gold nanoparticles as carriers by the transmucosal route in diabetic rats, thus showing considerable promise for further development.Abstract:
Nanomaterials have gained tremendous importance in biology and medicine because they can be used as carriers for delivering small molecules such as drugs, proteins, and genes. We report herein the binding of the hormone insulin to gold nanoparticles and its application in transmucosal delivery for the therapeutic treatment of diabetes mellitus. Insulin was loaded onto bare gold nanoparticles and aspartic acid-capped gold nanoparticles and delivered in diabetic Wistar rats by both oral and intranasal (transmucosal) routes. Our principle observations are that there is a significant reduction of blood glucose levels (postprandial hyperglycemia) when insulin is delivered using gold nanoparticles as carriers by the transmucosal route in diabetic rats. Furthermore, control of postprandial hyperglycemia by the intranasal delivery protocol is comparable to that achieved using the standard subcutaneous administration used for type I diabetes mellitus, thus showing considerable promise for further development.read more
Citations
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Gold nanoparticles in biomedical applications: recent advances and perspectives
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Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging
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Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin
TL;DR: The studies indicate that oral and nasal administration of insulin loaded chitosan reduced gold nanoparticles has led to improved pharmacodynamic activity and prove to be promising in controlling the postprandial hyperglycemia.
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Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles.
Morteza Mahmoudi,Morteza Mahmoudi,Morteza Mahmoudi,Heinrich Hofmann,Barbara Rothen-Rutishauser,Barbara Rothen-Rutishauser,Alke Petri-Fink +6 more
TL;DR: The following definitions for a nanoparticle (NP) and a nano-object will be used.
References
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Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid-liquid system
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Journal ArticleDOI
Nanostructures in Biodiagnostics
Nathaniel L. Rosi,Chad A. Mirkin +1 more
TL;DR: Nathaniel L. Rosi focuses on the rational assembly of DNA-modified nanostructures into larger-scale materials and their roles in biodiagnostic screening for nucleic acids.
Journal ArticleDOI
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Leon R. Hirsch,R.J. Stafford,James A. Bankson,S.R. Sershen,Belinda Rivera,Roger E. Price,John D. Hazle,Nancy J. Halas,Jennifer L. West +8 more
TL;DR: In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.
Journal ArticleDOI
Organization of 'nanocrystal molecules' using DNA
A. Paul Alivisatos,A. Paul Alivisatos,Kai Johnsson,Xiaogang Peng,Xiaogang Peng,Troy E. Wilson,Colin J. Loweth,Marcel P. Bruchez,Marcel P. Bruchez,Peter G. Schultz +9 more
TL;DR: A strategy for the synthesis of 'nanocrystal molecules', in which discrete numbers of gold nanocrystals are organized into spatially defined structures based on Watson-Crick base-pairing interactions is described.