Open AccessJournal Article
Growth hormone deficiency in adults with thalassemia: an overview and the I-CET recommendations.
Ashraf T Soliman,V De Sanctis,Heba Elsedfy,Mohamed A. Yassin,N Skordis,Mehran Karimi,Praveen Sobti,Giuseppe Raiola,M El Kholy +8 more
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This review paper provides a summary of the current state of knowledge regarding GHD and provides recommendations for the diagnosis and treatment of GHD in adult patients with thalassaemia major (TM).Abstract:
This review paper provides a summary of the current state of knowledge regarding GHD provides recommendations for the diagnosis and treatment of GHD in adult patients with thalassaemia major (TM). The reported prevalence of adult GHD and /or IGF-I deficiency in TM patients varies from 8% to 44 % in different centers. Because GH treatment requires analysis of many factors, including the effect of treatment on cardiac functions, metabolic parameters and psychosocial functioning, along with safety, ethical considerations, financial cost and other burdens of therapy, stringent diagnostic criteria are needed. The authors report the diagnostic recommendations of the International Study Group of Endocrine Complications in Thalassemia (I-CET) for adult TM patients.The pros and cons of GH treatment must be discussed with each patient, after which GH doses should be individualized and titrated to maximum efficacy with minimal side effects. Prospective studies to monitor potential benefits versus possible side-effects will enable endocrinologists to define recommendations on dosage and the long term effects, particularly on cardiovascular and bone status of GH therapy in adult TM patients.read more
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Bone disease in β thalassemia patients: past, present and future perspectives.
Vincenzo De Sanctis,Ashraf T Soliman,Heba Elsefdy,Nada Soliman,Elsaid M Aziz Bedair,Bernadette Fiscina,Christos Kattamis +6 more
TL;DR: Prevention, early recognition and treatment are the most effective strategies for the management of bone disease in patients with thalassemia major and TI who were conventionally treated in recent decades with frequent blood transfusions and iron chelation.
Journal Article
Osteoporosis in thalassemia major: an update and the I-CET 2013 recommendations for surveillance and treatment.
Vincenzo De Sanctis,Ashraf T Soliman,Heba Elsedfy,Mohamed A. Yassin,Duran Canatan,Yurdanur Kilinç,Praveen Sobti,Nicos Skordis,Mehran Karimi,Giuseppe Raiola,Maria Concetta Galati,Elsaid M Aziz Bedair,Bernadette Fiscina,Mohamed El Kholy,Endocrine Complications in Thalassemia +14 more
TL;DR: The use of bisphosphonates in TM patients with osteoporosis is increasing and their positive effect in improving bone mineral density is encouraging and the recommendations of the International Network on Growth Disorders and Endocrine Complications in Thalassaemia (I-CET) for diagnosis and management of osteoporeosis in TM are also briefly included in this review.
Growth and Growth hormone - Insulin Like Growth Factor -I (GH-IGF-I) Axis in Chronic Anemias.
TL;DR: The possible mechanisms that may impair growth in the different forms of anemias are addressed with special attention to their effect on the growth hormone – insulin like growth factor -I (IGF-I).
An ICET-A survey on occult and emerging endocrine complications in patients with β-thalassemia major: Conclusions and recommendations.
Vincenzo De Sanctis,Ashraf T Soliman,Duran Canatan,Ploutarchos Tzoulis,Shahina Daar,Salvatore Di Maio,Heba Elsedfy,Mohamed A. Yassin,Aldo Filosa,Nada Soliman,Karimi Mehran,Forough Saki,Praveen Sobti,Shruti Kakkar,Soteroula Christou,Alice Albu,Constantinos Christodoulides,Yurdanur Kilinç,Soad K. Al Jaouni,Doaa Khater,Saif Al-Yaarubi,Su Han Lum,Saveria Campisi,Salvatore Anastasi,Maria Concetta Galati,Giuseppe Raiola,Yasser Wali,Ihab Z. El-Hakim,Demetris Mariannis,Vassilis Ladis,Christos Kattamis +30 more
TL;DR: A survey on endocrine complications in adult thalassemia major patients provides a better understanding of physicians’ current clinical practices and beliefs in the detection, prevention and treatment of someendocrine complications prevailing in adult TM patients.
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