Guidelines for the laboratory investigation of heritable disorders of platelet function.
Paul Harrison,Ian J. Mackie,Andrew D Mumford,Carol Briggs,Ri Liesner,Mark Winter,Samuel J. Machin +6 more
TLDR
The objective of this guideline is to provide healthcare professionals with clear guidance on platelet function testing in patients with suspected bleeding disorders and in all cases individual patient circumstances may dictate an alternative approach.Abstract:
The guideline writing group was selected to be representative of UK-based medical experts. MEDLINE was systematically searched for publications in English up to the Summer of 2010 using key words platelet, platelet function testing and platelet aggregometry. Relevant references generated from initial papers and published guidelines/reviews were also examined. Meeting abstracts were not included. The writing group produced the draft guideline, which was subsequently revised and agreed by consensus. Further comment was made by members of the Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology. The guideline was then reviewed by a sounding board of approximately 40 UK haematologists, the British Committee for Standards in Haematology (BCSH) and the British Society for Haematology Committee and comments incorporated where appropriate. Criteria used to quote levels and grades of evidence are as outlined in appendix 7 of the Procedure for Guidelines Commissioned by the BCSH [http://www.bcshguidelines.com/BCSH_PROCESS/EVIDENCE_LEVELS_AND_GRADES_OF_RECOMMENDATION/43_GRADE.html]. The objective of this guideline is to provide healthcare professionals with clear guidance on platelet function testing in patients with suspected bleeding disorders. The guidance may not be appropriate to patients receiving antiplatelet therapy and in all cases individual patient circumstances may dictate an alternative approach.read more
Citations
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Journal ArticleDOI
Platelet Function tests: A Comparative Review
TL;DR: Well-tried and innovative platelet function tests and their methodological features and clinical applications are considered and different platelet methodologies for the evaluation of inherited and acquired bleeding disorders and for monitoring antiplatelet therapies are spreading.
Journal ArticleDOI
Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis
TL;DR: It is elucidates that platelets are not that innocent as they keep showing and thus numerous novel platelet biomarkers are upcoming very soon in the field of clinical research which can be important for predicting and diagnosing disease state.
Journal ArticleDOI
Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH
TL;DR: The consensus guidelines developed by a working party within the Platelet Physiology SSC are presented, using expert opinion, a literature review and feedback from public presentations.
Journal ArticleDOI
Identification of platelet function defects by multi-parameter assessment of thrombus formation
Susanne M. de Witt,Frauke Swieringa,Rachel Cavill,Moniek M. E. Lamers,Roger van Kruchten,Tom G. Mastenbroek,Constance C.F.M.J. Baaten,Susan L. Coort,Nicholas Pugh,Ansgar Schulz,Inge Scharrer,Kerstin Jurk,Barbara Zieger,Kenneth J. Clemetson,Richard W. Farndale,Johan W. M. Heemskerk,Judith M.E.M. Cosemans +16 more
TL;DR: A multi-surface and multi-parameter flow assay to characterize thrombus formation in whole blood from healthy subjects and patients with platelet function deficiencies is reported and suggests this test may be useful for the diagnosis of patients with suspected bleeding disorders or a pro-thrombotic tendency.
Journal ArticleDOI
Preanalytical quality improvement: in quality we trust.
Giuseppe Lippi,Kathleen Becan-McBride,D. Behulova,Raffick A.R. Bowen,Stephen Church,Joris R. Delanghe,Kjell Grankvist,Steve Kitchen,Mads Nybo,Matthias Nauck,Nora Nikolac,Vladimir Palicka,Mario Plebani,Sverre Sandberg,Ana-Maria Simundic +14 more
TL;DR: This collective paper provides additional contribution to risk management in the preanalytical phase and is a synopsis of the lectures of the 2nd European Federation of Clinical Chemistry and Laboratory Medicine-Becton Dickinson European Conference on Preanalytical Phase meeting entitled “Preanalytical quality improvement: in quality the authors trust” (Zagreb, Croatia, 1–2 March 2013).
References
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Journal ArticleDOI
The electronic aggregometer: a novel device for assessing platelet behavior in blood.
TL;DR: The new technique is very suitable for investigating platelet pharmacology, since the inhibitors of aggregation, such as indomethacin and prostacyclin, can be conveniently quantitated in blood by using this technique.
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A critical reappraisal of the bleeding time.
R P Rodgers,Jack Levin +1 more
TL;DR: The test is likely to remain widely used for the diagnosis of inherited disorders of platelet function, such as von Willebrand's syndrome, despite the lack of clear criteria for its use in this context.
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Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood
TL;DR: MEA is an easy, reproducible and sensitive method for measuring spontaneous and stimulated platelet aggregation, and evaluating antiplatelet drugs in diluted whole blood.
Journal ArticleDOI
The rare coagulation disorders – review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation
Paula H. B. Bolton-Maggs,D. J. Perry,Elizabeth Chalmers,L. A. Parapia,Jonathan T. Wilde,Michael Williams,Peter William Collins,Steve Kitchen,Gerry Dolan,Andrew D Mumford +9 more
TL;DR: This review summarizes the current literature for disorders of fibrinogen, and deficiencies of prothrombin, factor V, FV’+ VIII, FVII, FX, the combined vitamin K‐dependent factors, FXI and FXIII with a section on Ehlers‐Danlos Syndrome.
Journal ArticleDOI
The Relation of Blood Platelets to Hemorrhagic Disease: Description of a Method for Determining the Bleeding Time and Coagulation Time and Report of Three Cases of Hemorrhagic Disease Relieved by Transfusion
TL;DR: Three cases and experiments are reported which furnish additional evidence to show that the blood platelets play a part in stopping hemorrhage, and that one type of hemorrhagic disease may be attributed to an extreme reduction in the number of platelets.