Book ChapterDOI
H1-Antihistamines in the Elderly
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TLDR
In the elderly, H1-antihistamine therapy is commonly prescribed for treatment of rhinitis, conjunctivitis, pruritus, eczema, urticaria, and for prophylaxis of anaphylactoid reactions as mentioned in this paper.Abstract:
In the elderly, H1-antihistamine therapy is commonly prescribed for treatment of rhinitis, conjunctivitis, pruritus, eczema, urticaria, and for prophylaxis of anaphylactoid reactions. Second-generation H1-receptor antagonists provide excellent, safe, and effective alternatives to first-generation antihistamines in this population, as in younger patients. As with all medications, the choice of which agent to use must be tailored to the needs of the individual. Treatment should be planned with consideration of concomitant medications and potential drug-drug interactions and drug-disease interactions. First-generation antihistamines should not be used for treatment of allergic rhinitis or urticaria in the elderly. Age-related physiological changes can enhance or complicate the actions of H1-receptor antagonists, especially when these drugs are taken concurrently with other medications and/or in the presence of comorbid disease. Adjustments in dosages are necessary when some agents are used in patients with renal and/or hepatic disease; however, overall, the use of the newer nonsedating antihistamines is safe, effective, and gratifying in the elderly.read more
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Journal ArticleDOI
Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)
Jean Bousquet,N. Khaltaev,Alvaro A. Cruz,Judah A. Denburg,W. J. Fokkens,Alkis Togias,T. Zuberbier,Carlos E. Baena-Cagnani,Giorgio Walter Canonica,C. van Weel,Ioana Agache,Nadia Aït-Khaled,Claus Bachert,Michael S. Blaiss,Sergio Bonini,L.-P. Boulet,Philippe-Jean Bousquet,Paulo Augusto Moreira Camargos,K-H. Carlsen,Y. Z. Chen,Adnan Custovic,Ronald Dahl,Pascal Demoly,H. Douagui,Stephen R. Durham,R. Gerth van Wijk,O. Kalayci,Michael A. Kaliner,You Young Kim,Marek L. Kowalski,Piotr Kuna,L. T. T. Le,Catherine Lemière,Jing Li,Richard F. Lockey,S. Mavale-Manuel,Eli O. Meltzer,Y. Mohammad,J Mullol,Robert M. Naclerio,Robyn E O'Hehir,K. Ohta,S. Ouedraogo,S. Palkonen,Nikolaos G. Papadopoulos,Gianni Passalacqua,Ruby Pawankar,Todor A. Popov,Klaus F. Rabe,J Rosado-Pinto,G. K. Scadding,F. E. R. Simons,Elina Toskala,E. Valovirta,P. Van Cauwenberge,De Yun Wang,Magnus Wickman,Barbara P. Yawn,Arzu Yorgancioglu,Osman M. Yusuf,H. J. Zar,Isabella Annesi-Maesano,E.D. Bateman,A. Ben Kheder,Daniel A. Boakye,J. Bouchard,Peter Burney,William W. Busse,Moira Chan-Yeung,Niels H. Chavannes,A.G. Chuchalin,William K. Dolen,R. Emuzyte,Lawrence Grouse,Marc Humbert,C. M. Jackson,Sebastian L. Johnston,Paul K. Keith,James P. Kemp,J. M. Klossek,Désirée Larenas-Linnemann,Brian J. Lipworth,Jean-Luc Malo,Gailen D. Marshall,Charles K. Naspitz,K. Nekam,Bodo Niggemann,Ewa Nizankowska-Mogilnicka,Yoshitaka Okamoto,M. P. Orru,Paul Potter,David Price,Stuart W. Stoloff,Olivier Vandenplas,Giovanni Viegi,Dennis M. Williams +95 more
TL;DR: The ARIA guidelines for the management of allergic rhinitis and asthma are similar in both the 1999 ARIA workshop report and the 2008 Update as discussed by the authors, but the GRADE approach is not yet available.
Journal ArticleDOI
Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision
Jan Brozek,Jean Bousquet,Carlos E. Baena-Cagnani,Sergio Bonini,G. Walter Canonica,Thomas B. Casale,Roy Gerth van Wijk,Ken Ohta,Torsten Zuberbier,Holger J. Schünemann +9 more
TL;DR: These are the most recent and currently the most systematically and transparently developed recommendations about the treatment of allergic rhinitis in adults and children and patients are encouraged to use these recommendations in their daily practice and to support their decisions.
Journal ArticleDOI
Histamina, receptores de histamina e anti-histamínicos: novos conceitos
Paulo Ricardo Criado,Roberta Fachini Jardim Criado,Celina Wakisaka Maruta,Carlos D'Apparecida Machado Filho +3 more
TL;DR: New concepts of the role of histamine receptors (H1 receptors) are addressed, and the anti-inflammatory effects of these drugs are discussed and the pharmacokinetic and pharmacodynamic characteristics are discussed.
Histamina, receptores de histamina e anti-histamínicos: novos conceitos Histamine, histamine receptors and antihistamines: new concepts
TL;DR: In this paper, the role of histamine receptors (H1 receptors) and the anti-inflammatory effects of second generation antihistamines are discussed, and a comparison of first and second generation drugs is presented.
Journal ArticleDOI
Pharmacological management of allergic rhinitis in the elderly: safety issues with oral antihistamines.
TL;DR: Use of first-generation H1 receptor antagonists in the elderly should be considered carefully because of the large number of adverse effects and potential for interactions with these agents.