Hemoglobin A2 values in sickle cell disease patients quantified by high performance liquid chromatography and the influence of alpha thalassemia.
Silvana Fahel da Fonseca,Tatiana Amorim,Antônio Purificação,Marilda Souza Goncalves,Ney Boa-Sorte +4 more
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Hb A2 levels are elevated in patients with Hb S or Hb C, and are directly influenced by the alpha thalassemia genotypes.Abstract:
a b s t r a c t Background: In sickle cell disease, the quantification of Hb A2 is important for the differentialread more
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Vertebrate and invertebrate respiratory proteins, lipoproteins and other body fluid proteins
Ulrich Hoeger,J. R. Harris +1 more
TL;DR: This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles) and a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein.
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Techniques for the Detection of Sickle Cell Disease: A Review.
TL;DR: An overview of the current and emerging techniques for sickle cell disease detection and highlights the different potential methods that could be applied to help the early diagnosis of SCD can be found in this paper.
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Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
Amani M. Al-Amodi,Neda Z. Ghanem,Sumayh A Aldakeel,Lubna Ibrahim Al Asoom,Nazish Rafique Ahmed,Noor B. Almandil,Zaki A. Naserullah,Sana Al-Jarrash,Mohammed Shakil Akhtar,Sayed AbdulAzeez,Amein K. Al-Ali,J. Francis Borgio +11 more
TL;DR: HbA2 has a measure of unreliability in the diagnosis of β-thalassemia carriers, and can be incorrectly diagnosed as carriers.
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Knowledge of professional healthcare providers about sickle cell disease: Impact of a distance education course
Katy Karoline Santos Diniz,Adriana Silvina Pagano,Ana Paula Fernandes,Ilka Afonso Reis,Leonardo Gonçalves Pinheiro Júnior,Heloisa de Carvalho Torres +5 more
TL;DR: Participation in a distance education course on sickle cell disease had a positive impact on the acquisition of knowledge about the disease by professional healthcare providers.
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The importance of hemoglobin A2 determination.
TL;DR: Level was influenced by the genotype of -Thal, and the diagnosis of doubleheterozygous states, such as S- Thal, should be carried out care-fully, taking into consideration the limitations of the available laboratory techniques.
References
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Genetic association studies in -hemoglobinopathies
TL;DR: The review summarizes recent genetic studies and key genetic modifiers identified and traces the story of fetal hemoglobin genetics, which has led to an emerging network of globin gene regulation.
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Genetic association studies in β-hemoglobinopathies
TL;DR: In this article, a review summarizes recent genetic studies and key genetic modifiers identified and traces the story of fetal hemoglobin genetics, which has led to an emerging network of globin gene regulation.
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TL;DR: The field has rapidly expanded to regularly include capillary zone electrophoresis, molecular assays, and, more recently, mass spectrometric assays that have potential to translate into widespread clinical settings.
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Analysis of minor hemoglobins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Karin Zurbriggen,Markus Schmugge,Marlis Schmid,Silke Durka,Peter Kleinert,Thomas Kuster,Claus W. Heizmann,Heinz Troxler +7 more
TL;DR: The native and posttranslationally modified globin chains in minor and major Hbs are unambiguously identified by MALDI-TOF MS.
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Comparison of Sebia Capillarys Flex capillary electrophoresis with the BioRad Variant II high pressure liquid chromatography in the evaluation of hemoglobinopathies.
TL;DR: The Capillarys Flex is capable of identifying and quantifying hemoglobin species, consistent with existing HPLC methods.