Hemoglobin A2 values in sickle cell disease patients quantified by high performance liquid chromatography and the influence of alpha thalassemia.
Silvana Fahel da Fonseca,Tatiana Amorim,Antônio Purificação,Marilda Souza Goncalves,Ney Boa-Sorte +4 more
TLDR
Hb A2 levels are elevated in patients with Hb S or Hb C, and are directly influenced by the alpha thalassemia genotypes.Abstract:
a b s t r a c t Background: In sickle cell disease, the quantification of Hb A2 is important for the differentialread more
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Vertebrate and invertebrate respiratory proteins, lipoproteins and other body fluid proteins
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Techniques for the Detection of Sickle Cell Disease: A Review.
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Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
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The importance of hemoglobin A2 determination.
TL;DR: Level was influenced by the genotype of -Thal, and the diagnosis of doubleheterozygous states, such as S- Thal, should be carried out care-fully, taking into consideration the limitations of the available laboratory techniques.
References
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Journal ArticleDOI
Influence of hemoglobin S adducts on hemoglobin A2 quantification by HPLC.
D D Suh,J S Krauss,K Bures +2 more
Journal ArticleDOI
Some observations on the measurement of haemoglobin A2 and S percentages by high performance liquid chromatography in the presence and absence of α thalassaemia
TL;DR: There are significant differences in the haemoglobin A2 percentage in subjects with two, three, and four α genes, and this can be useful, together with the red cell indices, in predicting the likelihood of coexisting α thalassaemia.
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Quantification of HbA 2 in Patients With and Without β-Thalassemia and in the Presence of HbS, HbC, HbE, and HbD Punjab Hemoglobin Variants Comparison of Two Systems
TL;DR: The Capillarys 2 is superior to the VARIANT II for quantifying HbA(2) in the presence of HbE and HbD Punjab traits.
Journal Article
Chromatographic measurements of hemoglobin A2 in blood samples that contain sickle hemoglobin.
TL;DR: The results show that the Hb A2 levels in Hb S-containing samples partially overlap with those expected from beta-thalassemia carriers, which should be aware of.