Hepatitis B Virus-induced hFGL2 Transcription Is Dependent on c-Ets-2 and MAPK Signal Pathway
Meifang Han,Weiming Yan,Wei Guo,Dong Xi,Yaoyong Zhou,Weina Li,Sui Gao,Mingfeng Liu,Gary A. Levy,Xiaoping Luo,Qin Ning +10 more
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TLDR
C-Ets-2 protein was highly expressed in peripheral blood mononuclear cells from patients with severe chronic hepatitis B (CHB) in contrast to patients with mild CHB, and increased phosphorylation of ERK and JNK was detected in peripheralBlood mononnuclear cells from Patients with severe CHB.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-11-21 and is currently open access. It has received 47 citations till now. The article focuses on the topics: HBx & Transcription factor.read more
Citations
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Acute liver failure: mechanisms of immune-mediated liver injury.
TL;DR: This review summarizes current concepts of immune‐mediated liver injury from both clinical studies and animal models and highlights immune responses of ALF from the liver injury perspective, which combines a variety of molecular and cellular mechanisms, particularly, the contribution of cytokines and the innate immune system.
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Increased Killing of Liver NK Cells by Fas/Fas Ligand and NKG2D/NKG2D Ligand Contributes to Hepatocyte Necrosis in Virus-Induced Liver Failure
Yong Zou,Tao Chen,Meifang Han,Hongwu Wang,Weiming Yan,Ge Song,Zeguang Wu,Xiaojing Wang,Chuanlong Zhu,Xiaoping Luo,Qin Ning +10 more
TL;DR: NK cells play a pivotal role in the pathogenesis of FHF and HBV-ACLF, in which process Fas/FasL and NKG2D/NKG 2D ligand pathway contribute to the liver NK cell-mediated hepatocyte injury.
Journal ArticleDOI
Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients.
TL;DR: The frequency and cytokines secretion of circulating Th17 cells in HBV infected patients with different statuses are analyzed, and the potential association of Th17 frequency with the levels of liver injury is evaluated.
Journal ArticleDOI
Genome-wide analysis of host gene expression in the silkworm cells infected with Bombyx mori nucleopolyhedrovirus.
Aki Sagisaka,Kosuke Fujita,Yuki Nakamura,Jun Ishibashi,Hiroaki Noda,Shigeo Imanishi,Kazuei Mita,Minoru Yamakawa,Hiromitsu Tanaka +8 more
TL;DR: The global transcriptional profile of host genes in the silkworm cell line during the early phase of Bombyx mori nucleopolyhedrovirus (BmNPV) infection was analyzed and it was confirmed that the expression of 13 genes significantly increased and 7 genes significantly decreased after Bm NPV infection.
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Reactive Oxygen Species-Mediated c-Jun NH 2 -Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction.
TL;DR: It is demonstrated that HBx induced autophagosome formation independently of the class I phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway, while the class III PI3K(VPS34)/beclin-1 pathway was revealed to be crucial for this process.
References
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Hepatitis B core antigen is a potent inductor of interleukin-18 in peripheral blood mononuclear cells of healthy controls and patients with hepatitis B infection.
Tobias Manigold,Ulrich Böcker,Jingsan Chen,Jutta Gundt,Petra Traber,Manfred V. Singer,Siegbert Rossol +6 more
TL;DR: Results indicate that HBcAg induces IL‐18 secretion by induction of Caspase‐1, and differential regulation in HBeAg‐negative and positive patients suggests an important role of IL‐ 18 in CHB infection.
Journal ArticleDOI
Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells.
TL;DR: The results suggest an ERK1/2-dependent Ets2/PKC epsilon synergism to be involved in PTHrP expression in MCF-7 breast cancer cells.
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HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53
Andreas Klein,Eva Guhl,Yin-Jeh Tzeng,Jutta Fuhrhop,Massimo Levrero,M. Graessmann,Adolf Graessmann +6 more
TL;DR: It is shown here for the first time that HBX can immortalize ME-cells generated from mammary gland tissue segments in a p53-independent fashion and both cyclin D1 induction and HBX mitotic activity are dependent on p38 and c-Jun N-terminal kinase, but not on MEK-1 kinase activity.
Journal ArticleDOI
Hepatitis B virus X protein induces TNF-α expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2
TL;DR: It is suggested that HBx induces lipid peroxidation via down-regulation of SeP expression, resulting in increased expression of TNF-α in the human hepatoma cell line, HepG2.
Journal ArticleDOI
Protein kinase Calpha regulates Ets1 transcriptional activity in invasive breast cancer cells.
Ralph K. Lindemann,Melanie Braig,Pia Ballschmieter,Theresa A. Guise,Alfred Nordheim,Jürgen Dittmer +5 more
TL;DR: In this article, a constitutively active form of PKCalpha was found to potentiate the PTHrP P3 promoter activation by Ets1 alone and in synergy with Smad3.
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