Decoding cell death signals in liver inflammation.
Catherine Brenner,Catherine Brenner,Lorenzo Galluzzi,Lorenzo Galluzzi,Oliver Kepp,Oliver Kepp,Guido Kroemer +6 more
TLDR
The cellular and molecular mechanisms that account for the most deleterious effect of hepatic inflammation at the cellular level are discussed, that is, the initiation of a massive cell death response among hepatocytes.About:
This article is published in Journal of Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 696 citations till now. The article focuses on the topics: Innate immune system & Inflammation.read more
Citations
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Inflammatory responses and inflammation-associated diseases in organs
Linlin Chen,Huidan Deng,Hengmin Cui,Jing Fang,Zhicai Zuo,Junliang Deng,Yinglun Li,Xun Wang,Ling Zhao +8 more
TL;DR: Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds, potentially leading to tissue damage or disease.
Journal ArticleDOI
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents.
TL;DR: The tremendous clinical success of checkpoint blockers illustrates the potential of reestablishing latent immunosurveillance for cancer therapy, and their in-depth comprehension will facilitate the design of novel combinatorial regimens with improved clinical efficacy.
Journal ArticleDOI
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Lorenzo Galluzzi,J M Bravo-San Pedro,Ilio Vitale,Stuart A. Aaronson,John M. Abrams,Dieter Adam,Emad S. Alnemri,Lucia Altucci,David W. Andrews,Margherita Annicchiarico-Petruzzelli,Eric H. Baehrecke,Nicolas G. Bazan,Mathieu J.M. Bertrand,Mathieu J.M. Bertrand,Katiuscia Bianchi,Katiuscia Bianchi,Mikhail V. Blagosklonny,Klas Blomgren,Christoph Borner,Dale E. Bredesen,Dale E. Bredesen,Catherine Brenner,Catherine Brenner,Michelangelo Campanella,Eleonora Candi,Francesco Cecconi,Francis Ka-Ming Chan,Navdeep S. Chandel,Emily H. Cheng,Jerry E. Chipuk,John A. Cidlowski,Aaron Ciechanover,Ted M. Dawson,Valina L. Dawson,V De Laurenzi,R De Maria,Klaus-Michael Debatin,N. Di Daniele,Vishva M. Dixit,Brian David Dynlacht,Wafik S. El-Deiry,Gian Maria Fimia,Richard A. Flavell,Simone Fulda,Carmen Garrido,Marie-Lise Gougeon,Douglas R. Green,Hinrich Gronemeyer,György Hajnóczky,J M Hardwick,Michael O. Hengartner,Hidenori Ichijo,Bertrand Joseph,Philipp J. Jost,Thomas Kaufmann,Oliver Kepp,Daniel J. Klionsky,Richard A. Knight,Richard A. Knight,Sharad Kumar,Sharad Kumar,John J. Lemasters,Beth Levine,Beth Levine,Andreas Linkermann,Stuart A. Lipton,Richard A. Lockshin,Carlos López-Otín,Enrico Lugli,Frank Madeo,Walter Malorni,Jean-Christophe Marine,Seamus J. Martin,J-C Martinou,Jan Paul Medema,Pascal Meier,Sonia Melino,Noboru Mizushima,Ute M. Moll,Cristina Muñoz-Pinedo,Gabriel Núñez,Andrew Oberst,Theocharis Panaretakis,Josef M. Penninger,Marcus E. Peter,Mauro Piacentini,Paolo Pinton,Jochen H. M. Prehn,Hamsa Puthalakath,Gabriel A. Rabinovich,Kodi S. Ravichandran,Rosario Rizzuto,Cecília M. P. Rodrigues,David C. Rubinsztein,Thomas Rudel,Yufang Shi,Hans-Uwe Simon,Brent R. Stockwell,Brent R. Stockwell,Gyorgy Szabadkai,Gyorgy Szabadkai,Stephen W.G. Tait,H. L. Tang,Nektarios Tavernarakis,Nektarios Tavernarakis,Yoshihide Tsujimoto,T Vanden Berghe,T Vanden Berghe,Peter Vandenabeele,Peter Vandenabeele,Andreas Villunger,Erwin F. Wagner,Henning Walczak,Eileen White,W. G. Wood,Junying Yuan,Zahra Zakeri,Boris Zhivotovsky,Boris Zhivotovsky,Gerry Melino,Gerry Melino,Guido Kroemer +121 more
TL;DR: The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
Journal ArticleDOI
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
Zhenyu Zhong,Atsushi Umemura,Atsushi Umemura,Elsa Sanchez-Lopez,Shuang Liang,Shabnam Shalapour,Jerry Wong,Feng He,Daniela Boassa,Guy Perkins,Syed Raza Ali,Matthew D. McGeough,Mark H. Ellisman,Ekihiro Seki,Ekihiro Seki,Åsa B. Gustafsson,Hal M. Hoffman,Maria T. Diaz-Meco,Jorge Moscat,Michael Karin +19 more
TL;DR: The "NF-κB-p62-mitophagy" pathway is a macrophage-intrinsic regulatory loop through which NF-κBs restrains its own inflammation-promoting activity and orchestrates a self-limiting host response that maintains homeostasis and favors tissue repair.
Journal ArticleDOI
Hepatic stellate cells as key target in liver fibrosis
TL;DR: Cell type- and target-specific pharmacological intervention to therapeutically induce the deactivation of hepatic stellate cells will enable more effective and less toxic precision antifibrotic therapies.
References
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