Journal ArticleDOI
Heterocyclen aus CH-aciden Nitrilen, VIII. 2-Amino-thiophene aus methylenaktiven Nitrilen, Carbonylverbindungen und Schwefel
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TLDR
In this paper, the Einwirkung von Schwefel auf vinyloge methylenaktive Nitrile, gestattet auch die Einbeziehung von Alkylarylketonen in die Reaktion.Abstract:
Aliphatische Ketone, Aldehyde sowie β-Dicarbonylverbindungen reagieren mit methylenaktiven Nitrilen und Schwefel in Gegenwart von Aminen bei Raumtemperatur zu 2-Aminothiophenen. — Eine Variante der Synthese, die Einwirkung von Schwefel auf vinyloge methylenaktive Nitrile, gestattet auch die Einbeziehung von Alkylarylketonen in die Reaktion.read more
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Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives
TL;DR: The present review summarizes the recent developments of multicomponent reactions for the synthesis of biologically active molecules containing the pyrazole moiety and covers the articles published from 2015 to date related to antibacterial, anticancer, antifungal, antioxidant, α-glucosidase and α-amylase inhibitory, anti-inflammatory, antimycobacterial, antimalarial, and miscellaneous activities of pyrazoles obtained exclusively via an MCR.
Journal ArticleDOI
Basic Ionic Liquid [bmIm]OH–Mediated Gewald Reaction as Green Protocol for the Synthesis of 2-Aminothiophenes
TL;DR: A simple, efficient, and environmental friendly procedure was developed based on the Gewald reaction for the synthesis of 2-aminothiophenes using a basic ionic liquid [bmIm]OH as both catalyst and solvent.
Journal ArticleDOI
Design, Synthesis, and Antimicrobial Evaluation of Novel Thienopyrimidines and Triazolothienopyrimidines
TL;DR: In this paper, 2-Cyanoacetohydrazide and 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives were exploited as starting materials for the syntheses of novel thienopyrimidines and triazolothienopyridines.
Journal ArticleDOI
Notiz zur Reaktion von Ketonen mit Cyanessigsäurehydrazid und Schwefel
K. Gewald,I. Hofmann +1 more
TL;DR: Cyclohexanon und -heptanon reagieren basenkatalysiert with Schwefel and Cyanacethydrazid bzw. N-Acetylcyanacethyrazid zu Thieno[2,3d]pyrimidon-Derivaten, die sich zu 2-Amino-thiophencarbonsaure-(3)-hydraziden hydrolysieren lassen, wahrend das aus Cyclopentanon, Acetyl cyanac
Journal ArticleDOI
Convenient and Efficient Synthesis of Some Novel Fused Thieno Pyrimidines Using Gewald's Reaction
Ramakrishna Nirogi,Rama Sastri Kambhampati,Prabhakar Kothmirkar,Sobhanadri Arepalli,Narasimha Reddy G. Pamuleti,Shinde Anil Karbhari,P. K. Dubey +6 more
TL;DR: Several functionalized thienopyrimidines were synthesized by a facile synthetic method, which includes Gewald's reaction, and were characterized by spectral and analytical data as mentioned in this paper.
References
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Journal ArticleDOI
Heterocyclen aus CH-aciden Nitrilen, VII. 2-Amino-thiophene aus α-Oxo-mercaptanen und methylenaktiven Nitrilen
TL;DR: In this paper, the α-Oxo-mercaptane reagieren mit Nitrilen, die in α-Stellung eine aktive Methylengruppe besitzen, basenkatalysiert zu 2.3.
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