Journal ArticleDOI
Heterocyclen aus CH-aciden Nitrilen, VIII. 2-Amino-thiophene aus methylenaktiven Nitrilen, Carbonylverbindungen und Schwefel
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In this paper, the Einwirkung von Schwefel auf vinyloge methylenaktive Nitrile, gestattet auch die Einbeziehung von Alkylarylketonen in die Reaktion.Abstract:
Aliphatische Ketone, Aldehyde sowie β-Dicarbonylverbindungen reagieren mit methylenaktiven Nitrilen und Schwefel in Gegenwart von Aminen bei Raumtemperatur zu 2-Aminothiophenen. — Eine Variante der Synthese, die Einwirkung von Schwefel auf vinyloge methylenaktive Nitrile, gestattet auch die Einbeziehung von Alkylarylketonen in die Reaktion.read more
Citations
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Synthesis, computational, spectroscopic, hirshfeld surface, electronic state and molecular docking studies on diethyl-5-amino-3-methylthiophene-2,4-dicarboxylate
Aysha Fatima,Aysha Fatima,Ghazala Khanum,Sanjay K. Srivastava,Indresh Verma,Nazia Siddiqui,Saleem Javed +6 more
TL;DR: DAMC was synthesized, characterized, and investigated theoretically and by experimental spectroscopy as discussed by the authors, where surface analysis by Hirshfeld, and Spectrochemical analysis by NMR (1H NMR and 13C NMR), FT-IR, and UV-Visible were performed.
Journal ArticleDOI
One-Pot Synthesis of 4-Substituted 3-Amino-2-cyanothiophenes Involving O -Ethyl Thioformate
TL;DR: The thiophene core can be readily incorporated into more elaborate pharmaceutically relevant structures as demonstrated by converting 3-amino-2-cyano-4-phenylthiophene (1g) to various functionalized thieno[3,2-d]pyrimidines in only two steps.
Book ChapterDOI
Microwave-Assisted Syntheses in Organic Chemistry
TL;DR: In this article, a summary of typical organic chemical reactions selected, such as coupling reactions (C-C bond formation reactions, carbon-heteroatom bond formations), condensations (aldol-type-, Claisen-, Knoevenagel reaction), multicomponent reactions (Mannich-, Biginelli-, Hantzsch-, Bucherer-Bergs-, Strecker-, Gewald-, Kabachnik-Fields-, Kindler-, Passerini-, Ugi- and domino reactions), cycloadditions (including Diels-Alder reactions
Journal ArticleDOI
Synthesis of new fused pyrimidines by isocyanate and isothiocyanate.
TL;DR: o-Aminonitrile or o-aminoester compounds were cyclized to fused pyrimidines by reacting with ethyl iso(thio)cyanatoacetate in pyridine, and then were methylated, halogenated and subsequently displaced by the amines studied.
Journal ArticleDOI
Anticancer Activity Evaluation of New Thieno[2,3-d]pyrimidin-4(3H)-ones and Thieno[3,2-d]pyrimidin-4(3H)-one Derivatives
Olga Ya. Shyyka,Nazariy T. Pokhodylo,N. S. Finiuk,Vasyl S. Matiychuk,Rostyslav Stoika,Mykola D. Obushak +5 more
TL;DR: It was found that the most active compound among thienopyrimidine-4(3H)-ones is 2-(benzylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4-H)-one, which possesses cytotoxic activity on almost all cancer cell lines with mean growth 51.01%, where the most sensitive was the melanoma cell line MDA-MB-435 with GP (Growth Percent) =
References
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Journal ArticleDOI
Heterocyclen aus CH-aciden Nitrilen, VII. 2-Amino-thiophene aus α-Oxo-mercaptanen und methylenaktiven Nitrilen
TL;DR: In this paper, the α-Oxo-mercaptane reagieren mit Nitrilen, die in α-Stellung eine aktive Methylengruppe besitzen, basenkatalysiert zu 2.3.
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