Journal ArticleDOI
High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate.
TLDR
From results, a highly active cytochrome P450 system or non-enzymic oxidative reactions in aged rat tissue homogenate were suggested.About:
This article is published in Journal of Chromatography B: Biomedical Sciences and Applications.The article was published on 1994-02-11. It has received 22 citations till now. The article focuses on the topics: Fatty acid & Polyunsaturated fatty acid.read more
Citations
More filters
Journal ArticleDOI
Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs
TL;DR: A detailed compilation of the main oxylipins formed from PUFAs is provided and the understanding of the differing biological potencies, kinetics, and isomer-specific activities of these novel PUFA metabolites is described.
Journal ArticleDOI
Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids
Christophe Morisseau,Bora Inceoglu,Kara R. Schmelzer,Hsing Ju Tsai,Steven L. Jinks,Christine Hegedus,Bruce D. Hammock +6 more
TL;DR: An important function of epoxy-fatty acids in the n-3 series in modulating nociceptive signaling is supported and the DHA and eicosapentaenoic acid epoxides may be responsible for some of the beneficial effects associated with dietary n- 3 fatty acid intake.
Patent
Aspirin-triggered lipid mediators
Charles N. Serhan,Clary B. Clish +1 more
TL;DR: Aspirin triggered lipid mediators (ATLMs) are useful for the treatment or prevention of inflammation associated with various diseases, including ischemia as discussed by the authors, which can be useful for preventing or treating various diseases.
Patent
Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
Charles N. Serhan,Bruce D. Levy +1 more
TL;DR: In this paper, the authors describe isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA).
Journal ArticleDOI
Bisallylic hydroxylation and epoxidation of polyunsaturated fatty acids by cytochrome P450.
TL;DR: Epoxidation of polyunsaturated fatty acids is a prominent pathway of metabolism int he liver and the renal cortex and epoxygenase activity appears to be under homeostatic control in the kidney.
References
More filters
Journal ArticleDOI
Renal cytochrome P450-related arachidonate metabolite inhibits (Na + + K + )ATPase
TL;DR: In cells derived primarily from the mTALH of the outer medulla of rabbit kidney, a cytochrome P450-dependent monooxygenase system is identified which metabolizes arachidonic acid to two biologically active oxygenated products; one of the products inhibits (Na+ + K+)ATPase and the other relaxes blood vessels.
Journal ArticleDOI
Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.
TL;DR: All eight trihydroxy acids, formed by omega- or (omega-1)-hydroxylation of the four vic-diols, four vic -diol dicarboxylic acids, and other metabolites were identified by gas chromatography-mass spectrometry.
Journal ArticleDOI
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.
TL;DR: EETs are a labile class of vasodilators with a potency comparable to adenosine in the intestinal microcirculation and indirect evidence suggests regional differences in the formation of vasoactive quantities of arachidonate metabolites within the intestinal wall.
Journal ArticleDOI
Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids.
TL;DR: The structures for these intermediates are proposed on the basis of mass spectral interpretation of several derivatives including the lithium aluminum hydride reduction product of both natural and 18Oxygenated derivatives.
Journal ArticleDOI
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets
TL;DR: Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.
Related Papers (5)
Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions
Joan Clària,Charles N. Serhan +1 more