Highly flexible, wearable, and disposable cardiac biosensors for remote and ambulatory monitoring.
Stephen P. Lee,Grace Ha,Donald E. Wright,Yinji Ma,Ellora Sen-Gupta,Natalie R. Haubrich,Paul C. Branche,Weihua Li,Gilbert Lee Huppert,Matthew S. Johnson,Hakan Mutlu,Kan Li,Nirav Sheth,John Wright,Yonggang Huang,Moussa Mansour,John A. Rogers,Roozbeh Ghaffari +17 more
- Vol. 1, Iss: 1, pp 2-2
TLDR
Theoretical analyses of system-level bending mechanics show the advantages of WiSP’s flexible electronics, soft encapsulation layers and bioadhesives, enabling intimate skin coupling, and its physical attributes and performance results demonstrate its utility for monitoring cardiac signals during daily activity, exertion and sleep.Abstract:
Contemporary cardiac and heart rate monitoring devices capture physiological signals using optical and electrode-based sensors. However, these devices generally lack the form factor and mechanical flexibility necessary for use in ambulatory and home environments. Here, we report an ultrathin (~1 mm average thickness) and highly flexible wearable cardiac sensor (WiSP) designed to be minimal in cost (disposable), light weight (1.2 g), water resistant, and capable of wireless energy harvesting. Theoretical analyses of system-level bending mechanics show the advantages of WiSP’s flexible electronics, soft encapsulation layers and bioadhesives, enabling intimate skin coupling. A clinical feasibility study conducted in atrial fibrillation patients demonstrates that the WiSP device effectively measures cardiac signals matching the Holter monitor, and is more comfortable. WiSP’s physical attributes and performance results demonstrate its utility for monitoring cardiac signals during daily activity, exertion and sleep, with implications for home-based care. A highly flexible, low-power wearable sensor that harvests energy and monitors cardiac signals has been developed by Lee et al. The team was led by Dr. Roozbeh Ghaffari and co-workers at MC10 Inc. and Northwestern University’s Center for Bio-Integrated Electronics at the Simpson & Querrey Institute, in collaboration with the Massachusetts General Hospital and Tsinghua University. The novel wearable sensors measure cardiac signals comparable in signal fidelity to those achievable with expensive monitoring systems used in hospitals. Wearable health-care solutions are fundamentally changing the way we monitor our well-being at all times of the day, no matter whether we are asleep at home or busy at work. The sensors reported here are lightweight, inexpensive to manufacture, robust to everyday use, and capable of wireless data transmission and energy harvesting to and from a smartphone. The approach proved successful for measuring episodic electrocardiograms (ECG) and continuous heart rate signals with significantly higher patient comfort scores compared to standard Holter monitors in an initial pilot study conducted at the Massachusetts General Hospital (MGH).read more
Citations
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Bio-Integrated Wearable Systems: A Comprehensive Review
Tyler R. Ray,Jungil Choi,Amay J. Bandodkar,Siddharth Krishnan,Philipp Gutruf,Limei Tian,Roozbeh Ghaffari,John A. Rogers +7 more
TL;DR: This review summarizes the latest advances in this emerging field of "bio-integrated" technologies in a comprehensive manner that connects fundamental developments in chemistry, material science, and engineering with sensing technologies that have the potential for widespread deployment and societal benefit in human health care.
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Healthcare Blockchain System Using Smart Contracts for Secure Automated Remote Patient Monitoring
Kristen N. Griggs,Olya Ossipova,Christopher P. Kohlios,Alessandro N. Baccarini,Emily A. Howson,Thaier Hayajneh +5 more
TL;DR: This work created a system where sensors communicate with a smart device that calls smart contracts and writes records of all events on the blockchain, which would support real-time patient monitoring and medical interventions and automate the delivery of notifications to all involved parties in a HIPAA compliant manner.
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Flexible Electronics: Stretchable Electrodes and Their Future
TL;DR: In this paper, a review of the latest advances in stretchable transparent electrodes based on a new design strategy known as kirigami (the art of paper cutting) is presented.
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Wearable and Implantable Devices for Cardiovascular Healthcare: from Monitoring to Therapy Based on Flexible and Stretchable Electronics
TL;DR: Recent advances in wearable and implantable devices based on flexible and stretchable electronics for cardiovascular monitoring and therapy and device‐assisted tissue engineering therapy is discussed.
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Wearable sensors for monitoring the physiological and biochemical profile of the athlete
Dhruv R. Seshadri,Ryan T. Li,James E. Voos,James R. Rowbottom,Celeste M. Alfes,Christian A. Zorman,Colin K. Drummond +6 more
TL;DR: The emergence of flexible and stretchable electronics coupled with the ability to quantify biochemical analytes and physiological parameters have enabled the detection of key markers indicative of performance and stress, as reviewed in this paper.
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