Journal ArticleDOI
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
Eva Lonn,Salim Yusuf,J.M. Arnold,Janice Pogue,Mary Micks,Matthew J. McQueen,Jeffrey L. Probstfield +6 more
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TLDR
Supplements combining folic acid and vitamins B6 and B12 did not reduce the risk of major cardiovascular events in patients with vascular disease.Abstract:
risk, 0.95; 95 percent confidence interval, 0.84 to 1.07; P = 0.41). As compared with placebo, active treatment did not significantly decrease the risk of death from cardiovascular causes (relative risk, 0.96; 95 percent confidence interval, 0.81 to 1.13), myocardial infarction (relative risk, 0.98; 95 percent confidence interval, 0.85 to 1.14), or any of the secondary outcomes. Fewer patients assigned to active treatment than to placebo had a stroke (relative risk, 0.75; 95 percent confidence interval, 0.59 to 0.97). More patients in the active-treatment group were hospitalized for unstable angina (relative risk, 1.24; 95 percent confidence interval, 1.04 to 1.49). Conclusions Supplements combining folic acid and vitamins B 6 and B 12 did not reduce the risk of major cardiovascular events in patients with vascular disease. (ClinicalTrials.gov number, NCT00106886; Current Controlled Trials number, ISRCTN14017017.)read more
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Journal ArticleDOI
Estimated Stroke-Free Survival of Folic Acid Therapy for Hypertensive Adults: Projection Based on the CSPPT.
Tiantian Zhang,Tengfei Lin,Tengfei Lin,Yang Wang,Binyan Wang,Xianhui Qin,Feng Xie,Yimin Cui,Yong Huo,Xiaobin Wang,Zugui Zhang,Jie Jiang +11 more
TL;DR: Overall, besides significant benefit in certain subgroups, enalapril plus folic acid treatment for hypertensive patients is associated with a modest gain in lifetime stroke-free survival, compared with enalAPril alone.
Journal ArticleDOI
Risk factors for myocardial infarction in very young South Asians.
TL;DR: Established and emerging risk factors of CAD in South Asians are discussed, including low consumption of fruits and vegetables, smoking, alcohol, diabetes, psychosocial factors, sedentary lifestyle, abdominal obesity, hypertension and dyslipidemia.
Journal ArticleDOI
Advances in Stroke Prevention.
TL;DR: New oral anticoagulants that are not significantly more likely than aspirin to cause severe bleeding, and prolonged monitoring for atrial fibrillation (AF), have revolutionized the prevention of cardioembolic stroke.
Book ChapterDOI
Homocysteine in Red Blood Cells Metabolism - Pharmacological Approaches
TL;DR: Red blood cells are responsible for oxygen transport from lung to tissues and erythrocytes have intracellular enzyme/non enzyme defense system, but when reactive species are quickly and intensely generated under external/internal stimuli the activity of antioxidant defense system is overwhelmed.
References
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A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
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Journal ArticleDOI
Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
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Homocysteine and atherothrombosis
George N. Welch,Joseph Loscalzo +1 more
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