Journal ArticleDOI
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
Eva Lonn,Salim Yusuf,J.M. Arnold,Janice Pogue,Mary Micks,Matthew J. McQueen,Jeffrey L. Probstfield +6 more
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TLDR
Supplements combining folic acid and vitamins B6 and B12 did not reduce the risk of major cardiovascular events in patients with vascular disease.Abstract:
risk, 0.95; 95 percent confidence interval, 0.84 to 1.07; P = 0.41). As compared with placebo, active treatment did not significantly decrease the risk of death from cardiovascular causes (relative risk, 0.96; 95 percent confidence interval, 0.81 to 1.13), myocardial infarction (relative risk, 0.98; 95 percent confidence interval, 0.85 to 1.14), or any of the secondary outcomes. Fewer patients assigned to active treatment than to placebo had a stroke (relative risk, 0.75; 95 percent confidence interval, 0.59 to 0.97). More patients in the active-treatment group were hospitalized for unstable angina (relative risk, 1.24; 95 percent confidence interval, 1.04 to 1.49). Conclusions Supplements combining folic acid and vitamins B 6 and B 12 did not reduce the risk of major cardiovascular events in patients with vascular disease. (ClinicalTrials.gov number, NCT00106886; Current Controlled Trials number, ISRCTN14017017.)read more
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Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR.
TL;DR: Riboflavin is effective in reducing blood pressure specifically in patients with the MTHFR 677 TT genotype, and may have important implications for the prevention and treatment of hypertension.
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The molecular basis of homocysteine thiolactone-mediated vascular disease.
TL;DR: Recent evidence supporting the hypothesis that Hcy-thiolactone contributes to pathophysiological effects of Hcy on the vascular system is reviewed.
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Socioeconomic status as an independent predictor of physiological biomarkers of cardiovascular disease: evidence from NHANES.
TL;DR: Levels of "good" cholesterol increase with income and education even after controlling for factors known to place people at risk of high cholesterol.
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Homocysteine metabolism and its relation to health and disease
TL;DR: Intervention with B‐vitamin supplementation has been shown to successfully restore normal homocysteine concentrations, but without concomitant reductions in disease risk, so the mechanistic relation between homocy steine balance and disease states remains an area of intense investigation.
Journal ArticleDOI
The Role of Homocysteine‐Lowering B‐Vitamins in the Primary Prevention of Cardiovascular Disease
TL;DR: Studies undertaken with the aim of primary prevention have shown that vitamin B substitution may be effective in the primary prevention of CVD and may also be an option in the secondary prevention of disease if statin therapy is accompanied by serious adverse effects.
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A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
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Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
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Homocysteine and atherothrombosis
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