Journal ArticleDOI
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
Eva Lonn,Salim Yusuf,J.M. Arnold,Janice Pogue,Mary Micks,Matthew J. McQueen,Jeffrey L. Probstfield +6 more
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TLDR
Supplements combining folic acid and vitamins B6 and B12 did not reduce the risk of major cardiovascular events in patients with vascular disease.Abstract:
risk, 0.95; 95 percent confidence interval, 0.84 to 1.07; P = 0.41). As compared with placebo, active treatment did not significantly decrease the risk of death from cardiovascular causes (relative risk, 0.96; 95 percent confidence interval, 0.81 to 1.13), myocardial infarction (relative risk, 0.98; 95 percent confidence interval, 0.85 to 1.14), or any of the secondary outcomes. Fewer patients assigned to active treatment than to placebo had a stroke (relative risk, 0.75; 95 percent confidence interval, 0.59 to 0.97). More patients in the active-treatment group were hospitalized for unstable angina (relative risk, 1.24; 95 percent confidence interval, 1.04 to 1.49). Conclusions Supplements combining folic acid and vitamins B 6 and B 12 did not reduce the risk of major cardiovascular events in patients with vascular disease. (ClinicalTrials.gov number, NCT00106886; Current Controlled Trials number, ISRCTN14017017.)read more
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Journal ArticleDOI
Is High Homocysteine Level a Risk Factor for Cognitive Decline in Elderly? A Systematic Review, Meta-Analysis, and Meta-Regression
TL;DR: More prospective studies and randomized controlled trials are required to test the therapeutic benefits of lowering Hct levels, and the causal relationship between high-Hct level and risk of developing dementia is not supported.
Journal ArticleDOI
Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease—results of the renal Hope-2 study
Johannes F. E. Mann,Patrick Sheridan,Matthew J. McQueen,Claes Held,J. Malcolm O. Arnold,George Fodor,Salim Yusuf,Eva Lonn +7 more
TL;DR: Active treatment with B vitamins lowered homocysteine levels in participants with CKD but did not reduce cardiovascular risk.
Journal ArticleDOI
Dietary patterns and cardiovascular mortality in the Melbourne Collaborative Cohort Study
Linton Harriss,Dallas R. English,John Powles,Graham G. Giles,Andrew Tonkin,Allison M. Hodge,Laima Brazionis,Kerin O'Dea +7 more
TL;DR: It is suggested that frequent consumption of traditional Mediterranean foods is associated with reduced cardiovascular mortality after controlling for important risk factors and country of birth.
Journal ArticleDOI
Dietary supplement use and colorectal cancer risk: A systematic review and meta‐analyses of prospective cohort studies
Renate C. Heine-Bröring,Renate M. Winkels,Jacoba M S Renkema,Lea Kragt,Anne Claire B. van Orten-Luiten,Ettje F. Tigchelaar,Doris S. M. Chan,Teresa Norat,Ellen Kampman,Ellen Kampman,Ellen Kampman +10 more
TL;DR: Meta‐analyses of observational studies suggest a beneficial role for multivitamins and calcium supplements on colorectal cancer risk, while the association with other supplements and colore CT cancer risk is inconsistent.
Journal ArticleDOI
The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation.
TL;DR: Therapies targeting the epigenetic machinery as well as lowering circulating Hcy concentrations may have a more efficacious effect in reducing the incidence of cardiovascular complications.
References
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Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Stephen B. Hulley,Deborah Grady,Trudy L. Bush,Curt D Furberg,David M. Herrington,Betty Riggs,Eric Vittinghoff +6 more
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Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction.
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TL;DR: In this paper, the authors defined the definition of MI and established the following criteria for acute, evolving or recent MI: 1) Typical rise and gradual fall (troponin) or more rapid rise and fall (CK-MB) of biochemical markers of myocardial necrosis with at least one of the following: a) ischemic symptoms; b) development of pathologic Qwaves on the ECG; c) ECG changes indicative of ischemia (ST segment elevation or depression); or d) coronary artery intervention (e.g., coronary ang
Journal ArticleDOI
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
TL;DR: Higher folic acid intake by reducing tHcy levels promises to prevent arteriosclerotic vascular disease and under different assumptions, 13,500 to 50,000 CAD deaths annually could be avoided.
Journal ArticleDOI
Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
Joseph S. Alpert,Elliott M. Antman,Fred S. Apple,Paul W. Armstrong,J. P. Bassand,A. B. De Luna,George A. Beller,Günter Breithardt,Bernard R. Chaitman,Peter Clemmensen,Erling Falk,Michael C. Fishbein,Marcello Galvani,A Jr Garson,Cindy L. Grines,Christian W. Hamm,B. Nauheim,Uta C. Hoppe,Allan S. Jaffe,Hugo A. Katus,J. Kjeksus,Werner Klein,P. Klootwijk,C. Lenfant,Daniel Levy,R. I. Levy,Russell V. Luepker,F. Marcus,Ulf Näslund,Magnus Ohman,O. Pahlm,P. A. Poole-Wilson,R. Popp,Kalevi Pyörälä,Jan Ravkilde,N. Rehnquist,W. Roberts,Robert Roberts,J. Roelandt,Lars Rydén,Susana Sans,M. L. Simoons,Kristian Thygesen,Hugh Tunstall-Pedoe,Richard Underwood,Barry F. Uretsky,F. Van de Werf,L. M. Voipio-Pulkki,Galen S. Wagner,Lars Wallentin,William Wijns,David R. Wood +51 more
TL;DR: Biochemical markers of myocardial necrosis may have normalized, depending on the length of time that has passed since the infarct developed, and one of the following criteria satisfies the diagnosis for established MI: development of new pathologic Q waves on serial ECGs.
Journal ArticleDOI
Homocysteine and atherothrombosis
George N. Welch,Joseph Loscalzo +1 more
TL;DR: In 1969, McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma homocyst(e)ine concentrations and homocysteine thiolactone, and it has recently become clear that hyperhomocyst (e)inemia is an independent risk factor.
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