Journal ArticleDOI
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
Eva Lonn,Salim Yusuf,J.M. Arnold,Janice Pogue,Mary Micks,Matthew J. McQueen,Jeffrey L. Probstfield +6 more
Reads0
Chats0
TLDR
Supplements combining folic acid and vitamins B6 and B12 did not reduce the risk of major cardiovascular events in patients with vascular disease.Abstract:
risk, 0.95; 95 percent confidence interval, 0.84 to 1.07; P = 0.41). As compared with placebo, active treatment did not significantly decrease the risk of death from cardiovascular causes (relative risk, 0.96; 95 percent confidence interval, 0.81 to 1.13), myocardial infarction (relative risk, 0.98; 95 percent confidence interval, 0.85 to 1.14), or any of the secondary outcomes. Fewer patients assigned to active treatment than to placebo had a stroke (relative risk, 0.75; 95 percent confidence interval, 0.59 to 0.97). More patients in the active-treatment group were hospitalized for unstable angina (relative risk, 1.24; 95 percent confidence interval, 1.04 to 1.49). Conclusions Supplements combining folic acid and vitamins B 6 and B 12 did not reduce the risk of major cardiovascular events in patients with vascular disease. (ClinicalTrials.gov number, NCT00106886; Current Controlled Trials number, ISRCTN14017017.)read more
Citations
More filters
Journal ArticleDOI
Immunohistochemical detection of N-homocysteinylated proteins in humans and mice.
Joanna Perła-Kaján,Olaf Stanger,Michał Łuczak,Agnieszka Ziolkowska,Ludwik K. Malendowicz,Tomasz Twardowski,Šárka Lhoták,Richard C. Austin,Hieronim Jakubowski,Hieronim Jakubowski +9 more
TL;DR: In this article, the authors examined the utility of polyclonal rabbit anti-N-Hcy-protein IgG for the detection of N-homocysteinylated proteins in biological samples.
Journal ArticleDOI
Nutrition and Risk of Stroke.
TL;DR: It is now clear that B vitamins to lower homocysteine reduce the risk of stroke, but the authors should probably be using methylcobalamin instead of cyanocobalamin.
Journal ArticleDOI
Prospective study of homocysteine and MTHFR 677TT genotype and risk for venous thrombosis in a general population--results from the HUNT 2 study.
Inger Anne Næss,Sverre Christian Christiansen,Pål Richard Romundstad,Suzanne C. Cannegieter,Henk J. Blom,Frits R. Rosendaal,Jens Hammerstrøm +6 more
TL;DR: Elevated homocysteine levels in the general population predicted subsequent first VT in men but not in women, and the MTHFR 677TT genotype was not related to risk for VT.
Journal ArticleDOI
Homocysteine, vitamin B12 and folic acid levels in psoriatic patients and correlation with disease severity.
Valeria Brazzelli,Vincenzo Grasso,Luisa Fornara,Erica Moggio,G. Gamba,Simona Villani,Giovanni Borroni +6 more
TL;DR: A significantly higher prevalence of hyperhomocysteinaemia was found in psoriatic patients compared to healthy controls, and the data do not correlate the high level of homocysteine with higher PASI scores or psoriasis type, suggesting that homocy steine level can be considered an independent risk factor in psoratic patients.
Journal ArticleDOI
Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.
Rakesh S. Birjmohun,Menno Vergeer,Erik S.G. Stroes,Manjinder S. Sandhu,Sally L. Ricketts,Michael W.T. Tanck,Nicholas J. Wareham,J. Wouter Jukema,John J.P. Kastelein,Kay-Tee Khaw,S. Matthijs Boekholdt +10 more
TL;DR: It is shown that PON1-activity inversely relates to CAD risk, but not independent of HDL, due to its close association with the HDL-particle, which strongly suggest that a low PON2-activity is not a causal factor in atherogenesis.
References
More filters
Journal ArticleDOI
Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Stephen B. Hulley,Deborah Grady,Trudy L. Bush,Curt D Furberg,David M. Herrington,Betty Riggs,Eric Vittinghoff +6 more
TL;DR: Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease and the treatment did increase the rate of thromboembolic events and gallbladder disease.
Journal ArticleDOI
Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction.
Elliott M. Antman,Jean-Pierre Bassand,Werner Klein,Magnus Ohman,José Luis López Sendón,Lars Rydén,Maarten L. Simoons,Michal Tendera +7 more
TL;DR: In this paper, the authors defined the definition of MI and established the following criteria for acute, evolving or recent MI: 1) Typical rise and gradual fall (troponin) or more rapid rise and fall (CK-MB) of biochemical markers of myocardial necrosis with at least one of the following: a) ischemic symptoms; b) development of pathologic Qwaves on the ECG; c) ECG changes indicative of ischemia (ST segment elevation or depression); or d) coronary artery intervention (e.g., coronary ang
Journal ArticleDOI
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
TL;DR: Higher folic acid intake by reducing tHcy levels promises to prevent arteriosclerotic vascular disease and under different assumptions, 13,500 to 50,000 CAD deaths annually could be avoided.
Journal ArticleDOI
Myocardial infarction redefined - A consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction
Joseph S. Alpert,Elliott M. Antman,Fred S. Apple,Paul W. Armstrong,J. P. Bassand,A. B. De Luna,George A. Beller,Günter Breithardt,Bernard R. Chaitman,Peter Clemmensen,Erling Falk,Michael C. Fishbein,Marcello Galvani,A Jr Garson,Cindy L. Grines,Christian W. Hamm,B. Nauheim,Uta C. Hoppe,Allan S. Jaffe,Hugo A. Katus,J. Kjeksus,Werner Klein,P. Klootwijk,C. Lenfant,Daniel Levy,R. I. Levy,Russell V. Luepker,F. Marcus,Ulf Näslund,Magnus Ohman,O. Pahlm,P. A. Poole-Wilson,R. Popp,Kalevi Pyörälä,Jan Ravkilde,N. Rehnquist,W. Roberts,Robert Roberts,J. Roelandt,Lars Rydén,Susana Sans,M. L. Simoons,Kristian Thygesen,Hugh Tunstall-Pedoe,Richard Underwood,Barry F. Uretsky,F. Van de Werf,L. M. Voipio-Pulkki,Galen S. Wagner,Lars Wallentin,William Wijns,David R. Wood +51 more
TL;DR: Biochemical markers of myocardial necrosis may have normalized, depending on the length of time that has passed since the infarct developed, and one of the following criteria satisfies the diagnosis for established MI: development of new pathologic Q waves on serial ECGs.
Journal ArticleDOI
Homocysteine and atherothrombosis
George N. Welch,Joseph Loscalzo +1 more
TL;DR: In 1969, McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma homocyst(e)ine concentrations and homocysteine thiolactone, and it has recently become clear that hyperhomocyst (e)inemia is an independent risk factor.
Related Papers (5)
Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
Robert Clarke,Rory Collins,Sarah Lewington,Ann E. Donald,G. Alfthan,J. Tuomilehto,Egil Arnesen,Kaare H. Bønaa,Jacques Blacher,Godfried H.J. Boers,Andrew G. Bostom,M. L. Bots,D. E. Grobbee,Lars Brattström,Monique M.B. Breteler,A. Hofman,John C. Chambers,Jaspal S. Kooner,B. M. Coull,R. W. Evans,Lewis H. Kuller,S. Evers,Aaron R. Folsom,G. Freyburger,F. Parrot,J. Genest Jr,K. Dalery,I. M. Graham,Leslie Daly,Ellen K. Hoogeveen,Pieter J. Kostense,C.D.A. (Coen) Stehouwer,P. N. Hopkins,Paul F. Jacques,Jacob Selhub,F. C. Luft,P. Jungers,Arne Lindgren,Y. I. Lolin,F. Loehrer,Brian Fowler,Mohammad Azam Mansoor,M. R. Malinow,Pierre Ducimetière,Ottar Nygård,Helga Refsum,S. E. Vollset,Per Magne Ueland,G. S. Omenn,S. A. A. Beresford,J. M. Roseman,H. H. Parving,M. A. Gall,Ivan J. Perry,S Ebrahim,A. G. Shaper,Killian Robinson,D. W. Jacobsen,Steven M. Schwartz,David S. Siscovick,Meir J. Stampfer,C. H. Hennekens,Edith J. M. Feskens,Daan Kromhout,J. Ubbink,P. Elwood,J. Pickering,Petra Verhoef,A. Von Eckardstein,Helmut Schulte,Gerd Assmann,Nicholas J. Wald,M. R. Law,Peter H. Whincup,D. E. L. Wilcken,Paul Sherliker,P. Linksted,G Davey Smith +77 more