How mesenchymal stem cells interact with tissue immune responses
TLDR
A synthesis of the current status of mesenchymal stem cells is provided, which shows that there are bidirectional interactions between MSCs and inflammatory cells, which determine the outcome of MSC-mediated tissue repair processes.About:Â
This article is published in Trends in Immunology.The article was published on 2012-03-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Clinical uses of mesenchymal stem cells.read more
Citations
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Mesenchymal stem cells: immune evasive, not immune privileged
TL;DR: Protecting MSCs from immune detection and prolonging their persistence in vivo may improve clinical outcomes and prevent patient sensitization toward donor antigens.
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Mesenchymal stromal cells: sensors and switchers of inflammation.
TL;DR: Current insights into the ways in which MSCs sense and control inflammation are outlined, highlighting the central role of macrophage polarization and progress toward clinical application is discussed.
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Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications.
TL;DR: The current findings on the immunoregulatory plasticity of MSCs in disease pathogenesis and therapy are reviewed.
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Nitric oxide synthase in innate and adaptive immunity: an update
TL;DR: Findings from a comprehensive overview of the various sources and multiple reaction partners of NO, and of the regulation of NOS2 by micromilieu factors, antisense RNAs, and 'unexpected' cytokines are discussed.
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Immunobiology of mesenchymal stem cells
TL;DR: This review focuses on the crosstalk between MSCs and immune responses and their potential clinical applications, especially in inflammatory diseases.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
TL;DR: The vascular effects of EDRF released from perfused bovine intrapulmonary artery and vein were compared with the effects of NO delivered by superfusion over endothelium-denuded arterial and venous strips arranged in a cascade to determine whether nitric oxide (NO) is responsible for the vascular smooth muscle relaxation elicited by endothelia-derived relaxing factor (EDRF).
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Origin and Physiological Roles of Inflammation
TL;DR: This work has shown that tissue stress or malfunction induces an adaptive response that is intermediate between the basal homeostatic state and a classic inflammatory response, which is referred to here as para-inflammation.
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Human mesenchymal stem cells modulate allogeneic immune cell responses
TL;DR: Insight is offered into the interactions between allogeneic MSCs and immune cells and mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation.
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Mesenchymal stem cells in health and disease
TL;DR: The targets and mechanisms of M SC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches are discussed.