Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells.
TLDR
In this paper, the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells is presented, including the maintenance of mitochondrial organization and repair of mitochondrial DNA repair.Abstract:
Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles of H2S as an endogenously produced mammalian gaseous transmitter. Cystathionine -lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H2S-generating enzymes. In contrast to its inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, H2S serves as a stimulator of electron transport in mammalian mitochondria, by acting as an electron donor-with sulfide:quinone oxidoreductase (SQR) being the immediate electron acceptor. The mitochondrial roles of H2S are significant in various cancer cells, many of which exhibit high expression and partial mitochondrial localization of various H2S producing enzymes. In addition to the stimulation of mitochondrial ATP production, the roles of endogenous H2S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair (via the stimulation of the assembly of mitochondrial DNA repair complexes). The current article overviews the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells.read more
Citations
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Physiological roles of hydrogen sulfide in mammalian cells, tissues and organs.
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The Hidden Role of Hydrogen Sulfide Metabolism in Cancer.
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Emerging roles of cystathionine β-synthase in various forms of cancer
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Hydrogen Sulfide Biology and Its Role in Cancer
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TL;DR: This review will highlight the oncogenic role of H2S in the scientific community with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders.
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Selenium-Binding Protein 1 (SELENBP1) Supports Hydrogen Sulfide Biosynthesis and Adipogenesis.
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