Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells.
TLDR
In this paper, the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells is presented, including the maintenance of mitochondrial organization and repair of mitochondrial DNA repair.Abstract:
Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles of H2S as an endogenously produced mammalian gaseous transmitter. Cystathionine -lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H2S-generating enzymes. In contrast to its inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, H2S serves as a stimulator of electron transport in mammalian mitochondria, by acting as an electron donor-with sulfide:quinone oxidoreductase (SQR) being the immediate electron acceptor. The mitochondrial roles of H2S are significant in various cancer cells, many of which exhibit high expression and partial mitochondrial localization of various H2S producing enzymes. In addition to the stimulation of mitochondrial ATP production, the roles of endogenous H2S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair (via the stimulation of the assembly of mitochondrial DNA repair complexes). The current article overviews the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells.read more
Citations
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Physiological roles of hydrogen sulfide in mammalian cells, tissues and organs.
TL;DR: A wide array of significant roles of H2S in the physiological regulation of all organ functions emerges from this review.
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The Hidden Role of Hydrogen Sulfide Metabolism in Cancer.
TL;DR: In this article, the authors focus on the mechanism of H2S-mediated protein persulfidation and detailed information about the dysregulation of enzymes and metabolism in different cancer types.
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Emerging roles of cystathionine β-synthase in various forms of cancer
Kelly Ascencao,Csaba Szabó +1 more
TL;DR: In this paper , the authors reviewed the various tumorcell-supporting roles of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) axis in high-CBS expressor cancers and overviewed the anticancer effects of CBS silencing and pharmacological CBS inhibition in various cancer models in vitro and in vivo; they also outlined potential approaches for biomarker identification, to support future targeted cancer therapies based on pharmacologicalCBS inhibition.
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Hydrogen Sulfide Biology and Its Role in Cancer
Saadullah Khattak,Mohd Ahmar Rauf,Nazeer Hussain Khan,Qianqian Zhang,Hao Chen,Pir Muhammad,Mohammad Azam Ansari,Mohammad N. Alomary,Muhammad Jahangir,Chun Yang Zhang,Xin-Ying Ji,Dong-Dong Wu +11 more
TL;DR: This review will highlight the oncogenic role of H2S in the scientific community with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders.
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Selenium-Binding Protein 1 (SELENBP1) Supports Hydrogen Sulfide Biosynthesis and Adipogenesis.
TL;DR: In this article, the authors investigated whether selenium-binding-protein 1 (SELENBP1) plays a role in the regulation of adipocyte differentiation in vitro.
References
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Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide.
Yan Sun,Yaqian Huang,Wen Yu,Siyao Chen,Qiuyu Yao,Chunyu Zhang,Dingfang Bu,Chaoshu Tang,Junbao Du,Junbao Du,Hongfang Jin +10 more
TL;DR: It is suggested that H2S exerted vasorelaxant effect probably via sulfhydration-associated PDE 5A dimerization, and DTT partially abolished the effects of NaHS on Pde 5A activity, cGMP content and vasoreLaxation.
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Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II).
Karim Zuhra,Theodora Panagaki,Elisa B. Randi,Fiona Augsburger,Marc Blondel,Gaëlle Friocourt,Yann Herault,Csaba Szabó +7 more
TL;DR: While disulfiram did not exert any significant direct inhibitory effect on any of the H2S-producing enzymes, its metabolite, CuDDC was a potent inhibitor of CBS and CSE, and the mode of its action is likely related to the complexed copper molecule.
Journal ArticleDOI
The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria
TL;DR: The results suggest that Sqrdl transcription is adaptively regulated, probably to meet the need of H2S oxidation.