Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells.
TLDR
In this paper, the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells is presented, including the maintenance of mitochondrial organization and repair of mitochondrial DNA repair.Abstract:
Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles of H2S as an endogenously produced mammalian gaseous transmitter. Cystathionine -lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H2S-generating enzymes. In contrast to its inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, H2S serves as a stimulator of electron transport in mammalian mitochondria, by acting as an electron donor-with sulfide:quinone oxidoreductase (SQR) being the immediate electron acceptor. The mitochondrial roles of H2S are significant in various cancer cells, many of which exhibit high expression and partial mitochondrial localization of various H2S producing enzymes. In addition to the stimulation of mitochondrial ATP production, the roles of endogenous H2S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair (via the stimulation of the assembly of mitochondrial DNA repair complexes). The current article overviews the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells.read more
Citations
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Physiological roles of hydrogen sulfide in mammalian cells, tissues and organs.
TL;DR: A wide array of significant roles of H2S in the physiological regulation of all organ functions emerges from this review.
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The Hidden Role of Hydrogen Sulfide Metabolism in Cancer.
TL;DR: In this article, the authors focus on the mechanism of H2S-mediated protein persulfidation and detailed information about the dysregulation of enzymes and metabolism in different cancer types.
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Emerging roles of cystathionine β-synthase in various forms of cancer
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Hydrogen Sulfide Biology and Its Role in Cancer
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TL;DR: This review will highlight the oncogenic role of H2S in the scientific community with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders.
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Selenium-Binding Protein 1 (SELENBP1) Supports Hydrogen Sulfide Biosynthesis and Adipogenesis.
TL;DR: In this article, the authors investigated whether selenium-binding-protein 1 (SELENBP1) plays a role in the regulation of adipocyte differentiation in vitro.
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Book ChapterDOI
Role of H2S Donors in Cancer Biology
Zheng-Wei Lee,Lih-Wen Deng +1 more
TL;DR: In addition to promoting cancer cell death, H2S donors were also found to inhibit cancer angiogenesis and metastasis and the underlying mechanisms for the anticancer activities of H2s involve cell signaling pathways, cell cycle regulation, and cancer metabolism and pH regulation.
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