Identification of a novel acidic mammalian chitinase distinct from chitotriosidase
Rolf G. Boot,E. F. C. Blommaart,Erwin Swart,K. Ghauharali-Van der Vlugt,Nora Bijl,C. Moe,Allen R. Place,Johannes M. F. G. Aerts +7 more
TLDR
The study has revealed the existence of a chitinolytic enzyme in the gastrointestinal tract and lung that may play a role in digestion and/or defense.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-03-02 and is currently open access. It has received 489 citations till now. The article focuses on the topics: Chitinase & Chitinase-3-Like Protein 1.read more
Citations
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Biodegradation, biodistribution and toxicity of chitosan.
Thomas J. Kean,Maya Thanou +1 more
TL;DR: Research in this area is reviewed and chitosan's potential to be used as a generally regarded as safe (GRAS) material is critically discussed.
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Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
Zhou Zhu,Tao Zheng,Robert J. Homer,Yoon Keun Kim,Ning Yuan Chen,Lauren Cohn,Qutayba Hamid,Jack A. Elias +7 more
TL;DR: It is shown that acidic mammalian chitinase (AMCase) is induced via a T helper-2 (Th2)–specific, interleukin-13 (IL-13)–mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma.
Journal ArticleDOI
Chitin induces accumulation in tissue of innate immune cells associated with allergy
Tiffany A. Reese,Hong-Erh Liang,AndrewN M. Tager,Andrew D. Luster,Nico van Rooijen,David Voehringer,David Voehringer,Richard M. Locksley +7 more
TL;DR: It is shown that chitin induces the accumulation in tissue of IL-4-expressing innate immune cells, including eosinophils and basophils, when given to mice, and this process can be negatively regulated by a vertebrate chit inase.
Journal ArticleDOI
Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.
Chun Geun Lee,Carla A. Da Silva,Charles S. Dela Cruz,Farida Ahangari,Bing Ma,Min-Jong Kang,Chuan-Hua He,Seyedtaghi Takyar,Jack A. Elias +8 more
TL;DR: Levels of YKL-40 in the lung and serum are increased in asthma and other inflammatory and remodeling disorders and often correlate with disease severity, indicating understanding of the roles of C/CLPs in inflammation, tissue remodeling, and tissue injury in health and disease.
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Current views on fungal chitin/chitosan, human chitinases, food preservation, glucans, pectins and inulin: A tribute to Henri Braconnot, precursor of the carbohydrate polymers science, on the chitin bicentennial
Riccardo A.A. Muzzarelli,Joseph Boudrant,Diederick Meyer,Nicola Manno,Marta DeMarchis,Maurizio G. Paoletti +5 more
TL;DR: A review of the major research topics explored by Braconnot, and assesses their importance in the light of our most advanced knowledge is presented in this paper, where the value of fungi, seafoods and insects is described in connection with the significance of the presence of chitin itself in foods, and Chitinases in the human digestive system.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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New families in the classification of glycosyl hydrolases based on amino acid sequence similarities.
TL;DR: On the basis of a comparison of 482 sequences corresponding to 52 EC entries, 45 families, out of which 22 are polyspecific, can now be defined and has been implemented in the SWISS-PROT protein sequence data bank.
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Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease.
TL;DR: It is concluded that plasma chitotriosidase levels can serve as a new diagnostic hallmark of GD and should prove to be useful in assessing whether clinical manifestations of GD are present and for monitoring the efficacy of therapeutic intervention.
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Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.
TL;DR: The expression of HC gp-39 may be related to a response of human articular cartilage cells to an altered tissue environment, and significant homologies were observed with three mammalian secretory proteins of as yet unknown function, suggesting that a related protein family exists in mammals.
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Detection of chitinase activity after polyacrylamide gel electrophoresis
Jean Trudel,Alain Asselin +1 more
TL;DR: Commercial Streptomyces griseus and Serratia marcescens chitinases and purified wheat germ W1A and hen egg white lysozymes were subjected to polyacrylamide gel electrophoresis under native conditions at pH 4.3 and molecular weights of chitinolytic enzymes could be directly estimated.