Journal ArticleDOI
IMGT/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences.
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This article is published in CSH Protocols.The article was published on 2011-06-01. It has received 321 citations till now. The article focuses on the topics: T-cell receptor & Molecular Sequence Annotation.read more
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A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.
Chi Xiangyang,Renhong Yan,Jun Zhang,Zhang Guanying,Yuanyuan Zhang,Hao Meng,Zhe Zhang,Pengfei Fan,Dong Yunzhu,Yilong Yang,Chen Zhengshan,Yingying Guo,Jinlong Zhang,Yaning Li,Xiaohong Song,Chen Yi,Lu Xia,Ling Fu,Lihua Hou,Junjie Xu,Changming Yu,Jianmin Li,Qiang Zhou,Wei Chen +23 more
TL;DR: The epitope of 4A8 is defined as the N-terminal domain (NTD) of the S protein by determining with cryo–eletron microscopy its structure in complex with the Sprotein, which points to the NTD as a promising target for therapeutic mAbs against COVID-19.
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IgBLAST: an immunoglobulin variable domain sequence analysis tool
TL;DR: The sequence analysis tool IgBLAST is developed, which has the capability to analyse nucleotide and protein sequences and can process sequences in batches and allows searches against the germline gene databases and other sequence databases simultaneously to minimize the chance of missing possibly the best matching germline V gene.
Journal ArticleDOI
Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcripts.
Tobias Rogosch,Sebastian Kerzel,Kam Hon Hoi,Zhixin Zhang,Rolf F. Maier,Gregory C. Ippolito,Michael Zemlin +6 more
TL;DR: IgAT is a useful tool to gain insights into the selective forces and functional properties of small to extremely large collections of Ig transcripts, thereby assisting a researcher to mine a data set to its fullest.
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SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses.
Jackson S. Turner,Jane A. O’Halloran,Elizaveta Kalaidina,Wooseob Kim,Aaron J. Schmitz,Julian Q. Zhou,Tingting Lei,Mahima Thapa,Rita E. Chen,James Brett Case,Fatima Amanat,Adriana M Rauseo,Alem Haile,Xuping Xie,Michael K. Klebert,Teresa Suessen,William D. Middleton,Pei Yong Shi,Florian Krammer,Sharlene A. Teefey,Michael S. Diamond,Rachel M. Presti,Ali H. Ellebedy +22 more
TL;DR: In this article, the authors examined antigen-specific B-cell responses in peripheral blood and draining lymph nodes in 14 individuals who had received 2-doses of BNT162b2, an mRNA-based vaccine that encodes the full-length SARS-CoV-2 spike (S) gene1.
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IMGT®, the international ImMunoGeneTics information system® 25 years on
Marie-Paule Lefranc,Véronique Giudicelli,Patrice Duroux,Joumana Jabado-Michaloud,Géraldine Folch,Safa Aouinti,Emilie Carillon,Hugo Duvergey,Amélie Houles,Typhaine Paysan-Lafosse,Saida Hadi-Saljoqi,Souphatta Sasorith,Gérard Lefranc,Sofia Kossida +13 more
TL;DR: IMGT®, the international ImMunoGeneTics information system, is the global reference in immunogenetics and immunoinformatics and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data.
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Journal ArticleDOI
IMGT®, the international ImMunoGeneTics information system®
Marie-Paule Lefranc,Véronique Giudicelli,Chantal Ginestoux,Joumana Jabado-Michaloud,Géraldine Folch,Fatena Bellahcene,Yan-Yan Wu,Elodie Gemrot,Xavier Brochet,Jérôme Lane,Laetitia Regnier,François Ehrenmann,Gérard Lefranc,Patrice Duroux +13 more
TL;DR: IMGT, the international ImMunoGeneTics information system, was created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGénétique Moléculaire LIGM at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data.
Journal ArticleDOI
IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
TL;DR: IMGT/V-QUEST is the highly customized and integrated system for the standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) rearranged nucleotide sequences.
Journal ArticleDOI
IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains.
Marie-Paule Lefranc,Christelle Pommié,Quentin Kaas,Elodie Duprat,Nathalie Bosc,Delphine Guiraudou,Christelle Jean,Manuel Ruiz,Isabelle Da Piédade,Mathieu Rouard,Elodie Foulquier,Valérie Thouvenin,Gérard Lefranc +12 more
TL;DR: The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C- DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMains andC-LIke-DOMains of proteins other than IG andTR, in any species.
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Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
Kostas Stamatopoulos,Chrysoula Belessi,Carol Moreno,Myriam Boudjograh,Giuseppe Guida,Tatjana Smilevska,Lynda Belhoul,Stefania Stella,Niki Stavroyianni,Marta Crespo,Anastasia Hadzidimitriou,Laurent Sutton,Francesc Bosch,Nikolaos Laoutaris,Achilles Anagnostopoulos,Emili Montserrat,Athanasios Fassas,Guillaume Dighiero,Federico Caligaris-Cappio,Hélène Merle-Béral,Paolo Ghia,Frederic Davi +21 more
TL;DR: It is suggested that a particular antigen-binding site can be critical in determining the clinical features and outcome for at least some CLL patients.
Journal ArticleDOI
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
TL;DR: IMGT/GENE-DB is the comprehensive IMGT genome database for immunoglobulin (IG) and T cell receptor (TR) genes from human and mouse, and, in development, from other vertebrates.