Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia.
Hiroko Odani,Toru Shinzato,Jun Usami,Yoshihiro Matsumoto,Elisabeth Brinkmann Frye,John W. Baynes,Kenji Maeda +6 more
TLDR
Levels of GOLD and MOLD are significantly elevated in sera of non‐diabetic uremic patients, compared to age‐matched controls, and represent a major class of non-enzymatic, Maillard reaction crosslinks in plasma proteins, implicating oxidative stress and resultant advanced glycation and lipoxidation reactions in tissue damage in uremia.About:
This article is published in FEBS Letters.The article was published on 1998-05-15 and is currently open access. It has received 130 citations till now. The article focuses on the topics: Methylglyoxal & Glycation.read more
Citations
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Journal ArticleDOI
Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes.
TL;DR: A better understanding of the biochemical mechanisms by which AGEs contribute to such processes in the vessel wall could be relevant to devise preventive and therapeutic strategies for diabetic atherosclerosis.
Journal ArticleDOI
Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.
TL;DR: The human health risks from clinical and animal research studies are reviewed, including aldehydes as haptens in allergenic hypersensitivity diseases, respiratory allergies, and idiosyncratic drug toxicity; the potential carcinogenic risks of the carbonyl body burden.
Journal ArticleDOI
Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications
Toshio Miyata,Toshio Miyata,Toshio Miyata,Charles van Ypersele de Strihou,Charles van Ypersele de Strihou,Charles van Ypersele de Strihou,Kiyoshi Kurokawa,Kiyoshi Kurokawa,Kiyoshi Kurokawa,John W. Baynes,John W. Baynes,John W. Baynes +11 more
TL;DR: Uremia may be described as a state of carbonyl overload or "carbonyl stress" resulting from either increased oxidation of carbohydrates and lipids (oxidative stress) or inadequate detoxification or inactivation of reactive carbonyL compounds derived from both carbohydrates andlipids by oxidative and nonoxidatives.
Journal ArticleDOI
Novel inhibitors of advanced glycation endproducts
Samuel Rahbar,James L. Figarola +1 more
TL;DR: A new class of compounds are developed as potent inhibitors of glycation and AGE formation, including aryl (and heterocyclic) ureido, and ary l carboxamido phenoxy isobutyric acids and related molecules, which were found by in vitro assay methods to be potent inhibitors.
Journal ArticleDOI
Advanced glycation end products: A nephrologist's perspective
TL;DR: There is an exciting possibility that the complications of diabetes, uremia, and aging may be prevented with these novel agents.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal Article
Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.
Journal ArticleDOI
The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions.
Min-Xin Fu,Jesús R. Requena,Alicia J. Jenkins,Timothy J. Lyons,John W. Baynes,Suzanne R. Thorpe +5 more
TL;DR: The results suggest that lipid peroxidation, as well as glycoxidation, may be an important source of CML in tissue proteins in vivo and that CML may be a general marker of oxidative stress and long term damage to protein in aging, atherosclerosis, and diabetes.
Journal ArticleDOI
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.
Mahtab U. Ahmed,Elisabeth Brinkmann Frye,Thorsten P. Degenhardt,Suzanne R. Thorpe,John W. Baynes +4 more
TL;DR: Levels of CML and CEL are proposed to provide an index of glyoxal and methylglyoxal concentrations in tissues, alterations in glutathione homoeostasis and dicarbonyl metabolism in disease, and sources of advanced glycation end-products in tissue proteins in aging and disease.
Journal ArticleDOI
Glycation and diabetic complications
TL;DR: A review of the mechanisms behind advanced glycation end products (AGEs) play a central role in the pathogenesis of diabetic complications and their effects on diabetic pathology concludes with a summary of AGE inhibition.
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