Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences
Reads0
Chats0
TLDR
A review of the current knowledge of how immunosuppressive treatment (IST) changes the Gut Microbiota (GM) can be found in this article , with a consistent increase in proteobacteria including opportunistic pathobionts.About:
This article is published in American Journal of Transplantation.The article was published on 2022-04-01 and is currently open access. It has received 16 citations till now. The article focuses on the topics: Dysbiosis & Tacrolimus.read more
Citations
More filters
Journal ArticleDOI
Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation
Amedeo Lonardo,Alessandro Mantovani,Salvatore Petta,Amedeo Carraro,Christopher D. Byrne,Giovanni Targher +5 more
TL;DR: The putative metabolic mechanisms underlying the emergence of NAFLD or NASH after liver transplantation as well as optimal therapeutic approaches for recipients of liver transplants, including the management of cardiometabolic comorbidities, tailored immunosuppression, lifestyle changes and pharmacotherapy are discussed.
Journal ArticleDOI
Pathogenetic Mechanisms of Liver-Associated Injuries, Management, and Current Challenges in COVID-19 Patients
Muhammad Naeem,Naheed Bano,Saba Manzoor,Aftab Ahmad,Nayla Munawar,Saiful Izwan Abd Razak,Tze Yan Lee,Sutha Devaraj,Abu Hazafa +8 more
TL;DR: In this paper , the authors highlighted the attack of SARS-CoV-2 on liver hepatocytes by exploring the cellular and molecular events underlying the pathophysiological mechanisms in COVID-19 patients with liver injury.
Journal ArticleDOI
The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?
Yuselys García-Martínez,Margherita Borriello,Giovanna Capolongo,Diego Ingrosso,Alessandra F. Perna +4 more
TL;DR: In this paper , the authors studied the therapeutic potential of the gut microbiota in kidney transplantation and found that modifying the gut microbial signatures could potentially contribute to personalizing immunosuppressive and post-transplant complication therapies to improve graft survival and patients' quality of life.
Journal ArticleDOI
Oral antibiotics lower mycophenolate mofetil drug exposure, possibly by interfering with the enterohepatic recirculation: A case series
Mirjam Simoons,Kishan A. T. Naipal,Huib de Jong,Caroline M. den Hoed,Brenda C. M. de Winter,Midas B. Mulder +5 more
TL;DR: In this paper , the active mycophenolic acid (MPA) exposure severely decreased after oral antibiotic coadministration, which could result in rejection in solid organ transplant recipients, especially when therapeutic drug monitoring frequency is low.
Journal ArticleDOI
The Effect of the Gut Microbiota on Transplanted Kidney Function
Jarosław Przybyciński,Sylwester Drożdżal,Aleksandra Wilk,Violetta Dziedziejko,K. Szumilas,Andrzej Pawlik +5 more
TL;DR: In this article , the authors describe the effect of the microbiota on the transplanted kidney in renal transplant recipients and describe how probiotics of faecal microbiota trapoinsplantation can improve graft tolerance.
References
More filters
Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
A core gut microbiome in obese and lean twins
Peter J. Turnbaugh,Micah Hamady,Tanya Yatsunenko,Brandi L. Cantarel,Alexis E. Duncan,Ruth E. Ley,Mitchell L. Sogin,William J. Jones,Bruce A. Roe,Jason P. Affourtit,Michael Egholm,Bernard Henrissat,Andrew C. Heath,Rob Knight,Jeffrey I. Gordon +14 more
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Morgan G. I. Langille,Jesse R. Zaneveld,J. Gregory Caporaso,J. Gregory Caporaso,Daniel McDonald,Dan Knights,Joshua A Reyes,Jose C. Clemente,Deron E. Burkepile,Rebecca Vega Thurber,Rob Knight,Rob Knight,Robert G. Beiko,Curtis Huttenhower,Curtis Huttenhower +14 more
TL;DR: The results demonstrate that phylogeny and function are sufficiently linked that this 'predictive metagenomic' approach should provide useful insights into the thousands of uncultivated microbial communities for which only marker gene surveys are currently available.
Journal ArticleDOI
Obesity alters gut microbial ecology
Ruth E. Ley,Fredrik Bäckhed,Peter J. Turnbaugh,Catherine A. Lozupone,Robin D. Knight,Jeffrey I. Gordon +5 more
TL;DR: Analysis of the microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet, indicates that obesity affects the diversity of the gut microbiota and suggests that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.