Immunotherapy for cancer: synthetic carbohydrate-based vaccines
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TLDR
Recent advances in the development of fully synthetic sub-unit carbohydrate-based cancer vaccines will be discussed.About:
This article is published in Chemical Communications.The article was published on 2009-09-02 and is currently open access. It has received 201 citations till now. The article focuses on the topics: Synthetic vaccine.read more
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Glycosylation in cancer: mechanisms and clinical implications
Salomé S. Pinho,Celso A. Reis +1 more
TL;DR: The roles of glycans are highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention.
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Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research
TL;DR: Synthetic oligosaccharides and glycoconjugates are increasingly used as probes for biological research and as lead compounds for drug and vaccine discovery, and the power of carbohydrate chemistry is highlighted by an ability to synthesize glycoproteins.
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Emerging Principles for the Therapeutic Exploitation of Glycosylation
TL;DR: The current knowledge of glycans in pathogen invasion, cancer, autoimmunity, and congenital diseases is reviewed and glycan engineering will continue to deliver enhanced therapeutic glycoproteins, such as antibodies, with enhanced disease modifying properties.
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Recent Advances in Subunit Vaccine Carriers
TL;DR: This review details recent breakthroughs in the design of nano-particulate vaccine carriers, including liposomes, polymeric nanoparticles, and inorganic nanoparticles.
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Magnetic glyco-nanoparticles: a tool to detect, differentiate, and unlock the glyco-codes of cancer via magnetic resonance imaging.
Kheireddine El-Boubbou,David C. Zhu,Chrysoula Vasileiou,Babak Borhan,Davide Prosperi,Wei Li,Xuefei Huang +6 more
TL;DR: A magnetic glyco-nanoparticle (MGNP) based nanosensor system bearing carbohydrates as the ligands is reported, not only to detect and differentiate cancer cells but also to quantitatively profile their carbohydrate binding abilities by magnetic resonance imaging (MRI).
References
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Click Chemistry: Diverse Chemical Function from a Few Good Reactions.
TL;DR: In this paper, a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach called click chemistry is defined, enabled, and constrained by a handful of nearly perfect "springloaded" reactions.
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Toll-like receptors: critical proteins linking innate and acquired immunity.
TL;DR: Evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses.
PatentDOI
Synthesis of proteins by native chemical ligation
TL;DR: The technique of native chemical ligation is employable for chemically synthesizing full length proteins as discussed by the authors, which are chemically identical to proteins produced by cell free synthesis, and can be refolded and/or oxidized to form native disulfide-containing protein molecules.
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Glycosylation in Cellular Mechanisms of Health and Disease
Kazuaki Ohtsubo,Jamey D. Marth +1 more
TL;DR: This review discusses the increasingly sophisticated molecular mechanisms being discovered by which mammalian glycosylation governs physiology and contributes to disease.