Recent Advances in Subunit Vaccine Carriers
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TLDR
This review details recent breakthroughs in the design of nano-particulate vaccine carriers, including liposomes, polymeric nanoparticles, and inorganic nanoparticles.About:
This article is published in Vaccine.The article was published on 2016-04-19 and is currently open access. It has received 236 citations till now. The article focuses on the topics: Attenuated vaccine & Immunogenicity.read more
Citations
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Delivery technologies for cancer immunotherapy
TL;DR: How recent developments in drug delivery could enable new cancer immunotherapies and improve on existing ones are discussed, and the current delivery obstacles are examined.
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COVID-19 Vaccine Frontrunners and Their Nanotechnology Design.
TL;DR: This review analyzes these frontrunners in the vaccine development space and delves into their posted results while highlighting the role of the nanotechnologies applied by all the vaccine developers.
Journal ArticleDOI
The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation.
TL;DR: This review described the COVID-19 vaccines that are currently tested in clinical trials and provided in-depth insight into the various types of vaccines, their compositions, advantages, and potential limitations.
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In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases.
Robert Adamu Shey,Robert Adamu Shey,Stephen Mbigha Ghogomu,Kevin K Esoh,Neba Derrick Nebangwa,Cabirou Mounchili Shintouo,Nkemngo Francis Nongley,Bertha Fru Asa,Ferdinand Njume Ngale,Ferdinand Njume Ngale,Luc Vanhamme,Jacob Souopgui +11 more
TL;DR: An immuno-informatics approach was applied to design a filarial multi-epitope subunit vaccine peptide consisting of linear B-cell and T-cell epitopes of proteins reported to be potential novel vaccine candidates that demonstrated antigenicity superior to current vaccine candidates.
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Nanomaterials for cancer immunotherapy.
TL;DR: The basic principles of cancer immunotherapy are summarized, why and where to apply nanomaterials are explained, and special emphasis on cancer vaccines and tumor microenvironment modulation are put on.
References
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Innate Immune Recognition
TL;DR: Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
TL;DR: It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
Journal ArticleDOI
Liposome: classification, preparation, and applications
Abolfazl Akbarzadeh,Rogaie Rezaei-Sadabady,Rogaie Rezaei-Sadabady,Soodabeh Davaran,Sang Woo Joo,Nosratollah Zarghami,Younes Hanifehpour,Mohammad Samiei,Mohammad Kouhi,Kazem Nejati-Koshki +9 more
TL;DR: This paper summarizes exclusively scalable techniques and focuses on strengths and limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.
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Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.
TL;DR: A simple, non-invasive procedure that takes advantage of the strong near infrared (NIR) absorption of nanoshells, a new class of gold nanoparticles with tunable optical absorptivities that can undergo passive extravasation from the abnormal tumor vasculature due to their nanoscale size.
Journal ArticleDOI
Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)
TL;DR: This research attacked the mode of action of phosphatidylcholine-like deposits in response to the presence of ribonucleic acid by exploiting its role as a “spatially aggregating substance” in the response to EMT.
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