Journal ArticleDOI
Impact of structural changes in heteroleptic bismuth phosphinates on their antibacterial activity in Bi-nanocellulose composites
Megan E. Herdman,Melissa V. Werrett,Rebekah N. Duffin,Liam J. Stephens,Rajini Brammananth,Ross L. Coppel,Warren Batchelor,Philip C. Andrews +7 more
TLDR
Four mono-phosphinato bismuth complexes used to produce antibacterial nanocellulose composites displayed an increased level of toxicity towards mammalian cells (COS-7, human and murine fibroblasts), where it was shown the complexes disrupt cellular membranes leading to cytotoxicity.Abstract:
To study and evaluate the effect of ligand choice and distribution in bismuth phosphinates on toxicity and antibacterial activity, a series of novel diphenyl mono-phosphinato bismuth complexes, [BiPh2(O(O)P(H)Ph)] 1, [BiPh2(O(O)PPh2)] 2, [BiPh2(O(O)PMe2)] 3 and [BiPh2(O(O)P(p-MeOPh)2)] 4, were synthesised, characterised and structurally authenticated by X-ray crystallography. Evaluation of their antibacterial activity towards Staphylococcus aureus (S. aureus), methicillin-resistant S. aureus (MRSA), vancomycin-resistant Enterococci (VRE), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) showed all four mono-phosphinato bismuth complexes to be highly active. However, unlike their less soluble bis-phosphinato analogues, they displayed an increased level of toxicity towards mammalian cells (COS-7, human and murine fibroblasts), where it was shown the complexes disrupt cellular membranes leading to cytotoxicity. The mono-phosphinato bismuth complexes were used to produce antibacterial nanocellulose composites. Leaching studies showed that complex 1 had the highest levels of leaching, at 15% of the total available bismuth when the composite was soaked in water. The aqueous leachates of 1 were bacteriostatic towards MRSA and VRE at concentrations between 4.0 and 4.6 μM, while being bactericidal towards E. coli above 2.8 μM. At similar concentrations the complex showed toxicity towards human fibroblast cells, with cell viability reduced to 2% (1, 2.4 μM). The possibility to control leaching of the bismuth complexes from cellulose composites through structural changes is evidence for their potential application in antibacterial surfaces and materials.read more
Citations
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Journal ArticleDOI
Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles.
TL;DR: Bismuth is a relatively non-toxic and inexpensive metal with exceptional properties has numerous biomedical applications as discussed by the authors, and it is used extensively as medicines for the treatment of gastrointestinal disorders including dyspepsia, gastric ulcers and H. pylori infections.
Journal ArticleDOI
X-ray structures, spectroscopic, antimicrobial activity, ESP/HSA and TD/DFT calculations of Bi(III) complex containing imidazole ring
TL;DR: In this paper , a quinazoline ligand with Bi(III) nitrate pentahydrate in methanol and ethyl acetate was synthesized, and the structure of the complex was determined by elemental analysis, FT-IR, UV-vis and fluorescence spectroscopy, as well as characterized by X-ray crystallography.
Journal ArticleDOI
Building a Green, Robust, and Efficient Bi-MOF Heterogeneous Catalyst for the Strecker Reaction of Ketones
E. P. Gómez-Oliveira,Nayara Méndez,Marta Iglesias,Enrique Gutiérrez-Puebla,Lina María Aguirre-Díaz,M. Angeles Monge +5 more
TL;DR: In this article , the authors presented the BiPF-4 (bismuth polymeric framework-4) MOF and its behavior as a heterogeneous catalyst in the multicomponent organic Strecker reaction, showing a three-dimensional (3D) framework formed by peculiar inorganic oxo-hydroxo-bismutate layers connected among them through the 3,5-dsb linker.
Journal ArticleDOI
Two mono‐ and dinuclear Bi (III) complexes combined with crystallographic, spectroscopic, antibacterial activities, MEP/HSA, and TD/DFT calculations
TL;DR: In this article , two mono-and dinuclear Bi (III) complexes, [Bi(L)2(NO3)2]·NO3 (1) and [Bi2(L]2Cl8] (2) (L = (2-(2-pyridyl)-4-methyl-1,2-dihydroquinazoline-N3-oxide), were obtained via complexation of L with Bi(III) nitrate pentahydrate and Bi ( III) chloride.
Journal ArticleDOI
Bismuth(III) Thiophosphinates: Understanding How a Small Atomic Change Influences Antibacterial Activity and Mammalian Cell Viability
Dimuthu C. Senevirathna,Rebekah N. Duffin,Liam J. Stephens,Megan E. Herdman,Melissa V. Werrett,Philip C. Andrews +5 more
TL;DR: In this article, diphenylphosphinothioic acid (HSP(=O)Ph2) and HSP( =S)ph2) were used to synthesize four BiIII complexes: 1 [Bi(SP(O)PH2)3], 2 [BiPh(SP[O]Ph2]2], 3 [BiPH[SP[S]Ph 2], 4] using BiPh[OtBu] as bismuth sources.
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