Journal ArticleDOI
Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure.
V. Balasubramaniyan,Dipok Kumar Dhar,Anne E. Warner,Wai-Yin Vivien Li,Azin Farzan Amiri,Beverley Bright,Rajeshwar P. Mookerjee,Nathan Davies,David L. Becker,Rajiv Jalan +9 more
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TLDR
The results of this study show for the first time an increased expression of hepatic Cx43 in cirrhosis and ACLF, which was related to the severity of inflammation.About:
This article is published in Journal of Hepatology.The article was published on 2013-06-01. It has received 63 citations till now. The article focuses on the topics: Cirrhosis.read more
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Journal ArticleDOI
Connexins and their channels in inflammation.
Joost Willebrords,Sara Crespo Yanguas,Michaël Maes,Elke Decrock,Nan Wang,Luc Leybaert,Brenda R. Kwak,Colin R. Green,Bruno Cogliati,Mathieu Vinken +9 more
TL;DR: A state-of-the-art overview of the effects of inflammation on connexin signaling is provided and a better understanding of the importance of con Nexin signaling in inflammation may open up towards clinical perspectives.
Journal ArticleDOI
Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice
Xiaogang Xiang,Xiaogang Xiang,Dechun Feng,Seonghwan Hwang,Tianyi Ren,Xiaolin Wang,Eszter Trojnar,Csaba Mátyás,Ruidong Mo,Dabao Shang,Yong He,Wonhyo Seo,Vijay H. Shah,Pal Pacher,Qing Xie,Bin Gao +15 more
TL;DR: This severe liver injury model developed acute-on-chronic liver injury, bacterial infection, multi-organ injury, and high mortality, recapitulating some features of clinical ACLF, suggesting interleukin-22 (IL-22Fc) therapy may have therapeutic potential for ACLF treatment.
Journal ArticleDOI
Endothelial dysfunction in cirrhosis: Role of inflammation and oxidative stress
TL;DR: Improvement of NO availability in the hepatic circulation can be beneficial for the improvement of endothelial dysfunction and associated portal hypertension in patients with cirrhosis and therapeutic agents that are identified in increasing NO bioavailability through improvement of hepatic endothelial nitric oxide synthase (eNOS) activity.
Journal ArticleDOI
Infliximab improves endothelial dysfunction in systemic vasculitis: A model of vascular inflammation
A. D. Booth,D. R.W. Jayne,Rajesh K. Kharbanda,Carmel M. McEniery,Isla S. Mackenzie,John Brown,Ian B. Wilkinson +6 more
TL;DR: In this paper, the authors used anti-neutrophil cytoplasmic antibody-associated systemic vasculitis (AASV) as a model of systemic inflammation in which to test the hypothesis that inflammation is associated with endothelial dysfunction and can be reversed with anti-tumor necrosis factor-α (TNF-α) therapy.
Journal ArticleDOI
α V β 3 Integrin regulates astrocyte reactivity.
Raúl Lagos-Cabré,Alvaro Alvarez,Alvaro Alvarez,Milene Kong,Milene Kong,Francesca Burgos-Bravo,Areli Cárdenas,Edgardo Rojas-Mancilla,Ramón Pérez-Nuñez,Rodrigo Herrera-Molina,Fabiola Rojas,Pascal Schneider,Mario Herrera-Marschitz,Andrew F. G. Quest,Brigitte van Zundert,Lisette Leyton +15 more
TL;DR: Therefore, inflammation induces expression of αVβ3 Integrin and other proteins, astrocyte reactivity, and Thy-1 responsiveness, and ectopic control of β3 integrin levels modulates these responses regardless of inflammation.
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Journal ArticleDOI
Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions
TL;DR: The physiological role of gap junctions in several tissues has been elucidated by the discovery of mutant connexins associated with genetic diseases and by the generation of mice with targeted ablation of specific connexin genes.
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Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis.
Herbert Tilg,Rajiv Jalan,Arthur Kaser,Nathan Davies,Felix Offner,Stephen J. Hodges,Othmar Ludwiczek,Debbie L. Shawcross,Heinz Zoller,Akeel Alisa,Rajeshwar P. Mookerjee,Ivo Graziadei,Christian Datz,Michael Trauner,Detlef Schuppan,Peter Obrist,Wolfgang Vogel,Roger Williams +17 more
TL;DR: The data suggest that randomized controlled trials of anti-TNF antibody in severe AH are warranted, and there was an early, though not significant, decrease in plasma levels of proinflammatory cytokines, whereas Plasma levels of TNFalpha remained near the sensitivity limit of the assay throughout the treatment course.
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Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury.
TL;DR: Rats treated with Cx43-asODN showed less swelling and tissue disruption, less up-regulation of astrocytic GFAP, and less extravasation of fluorescently-labelled bovine serum albumin and neutrophils, and may be a valuable target for therapeutic intervention.
Journal ArticleDOI
Infliximab Improves Endothelial Dysfunction in Systemic Vasculitis A Model of Vascular Inflammation
A. D. Booth,D. R.W. Jayne,Rajesh K. Kharbanda,Carmel M. McEniery,Isla S. Mackenzie,John Brown,Ian B. Wilkinson +6 more
TL;DR: AASV is associated with endothelial dysfunction and anti–TNF-&agr; therapy, alone or in combination with standard treatment, results in clinical remission, reduced inflammation, and improved endothelium-dependent vasomotor responses.