T
Tamara Vanhaecke
Researcher at Vrije Universiteit Brussel
Publications - 259
Citations - 6869
Tamara Vanhaecke is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Medicine & Cellular differentiation. The author has an hindex of 37, co-authored 230 publications receiving 5988 citations. Previous affiliations of Tamara Vanhaecke include VU University Amsterdam.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
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Molecular Mechanisms Underlying the Dedifferentiation Process of Isolated Hepatocytes and Their Cultures
Greetje Elaut,Tom Henkens,Peggy Papeleu,Sarah Snykers,Mathieu Vinken,Tamara Vanhaecke,Vera Rogiers +6 more
TL;DR: Identification of the conditions needed for the full in vitro maturation of hepatic progenitor cells to quiescent, functional hepatocyte-like cells opens promising perspectives.
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In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art
TL;DR: This review focuses on current strategies to differentiate embryonic, mesenchymal(‐like), and liver stem/progenitor cells into hepatocytes in vitro, and some recommendations are proposed to standardize, optimize, and enrich the in vitro production of hepatocyte‐like cells out of stem/ ProGenitor cells.
Journal ArticleDOI
Trichostatin A - like Hydroxamate Histone Deacetylase Inhibitors as Therapeutic Agents: Toxicological Point of View
TL;DR: The present review provides a state-of-the-art of the current knowledge of the pharmacological and toxicological effects on proliferating cells of TSA and its hydroxamate-based structural analogues.
Journal ArticleDOI
Connexin-related signaling in cell death: to live or let die?
Elke Decrock,Mathieu Vinken,E. De Vuyst,Dmitri V. Krysko,Katharina D'Herde,Tamara Vanhaecke,Peter Vandenabeele,Vera Rogiers,Luc Leybaert +8 more
TL;DR: Current knowledge on connexins and their channels in cell death is reviewed and the molecular mechanisms that underlie connexin-related signaling are addressed, including pannexins, a novel set of con Nexin-like proteins that have been implicated in cellular responses to pathological insults.