Open AccessJournal Article
In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L buds.
Francesco Bonina,Carmelo Puglia,Dario Ventura,Rita Patrizia Aquino,S Tortora,Antonia Sacchi,Antonella Saija,Antonio Tomaino,Maria Luisa Pellegrino,P de Caprariis +9 more
TLDR
From the results obtained in in vitro and in vivo tests, LECS showed a significant antioxidant effect and some flavonols (kaempferol and quercetin derivatives) and hydroxycinnamic acids (caffeic acid, ferulic acid, p-cumaric Acid, and cinnamic acid).Abstract:
The aim of the present study was to evaluate the in vitro antioxidant and in vivo photoprotective activities of a lyophilized extract of Capparis spinosa L. (LECS) obtained by methanolic extraction from the flowering buds of this plant. For the in vitro experiments, LECS was tested employing three different models: (a). bleaching of the stable 1,1-diphenyl-2-picrylhydrazyl radical (DPPH test); (b). peroxidation, induced by the water-soluble radical initiator 2,2'-azobis(2-amidinopropane) hydrochloride, of mixed dipalmitoylphosphatidylcholine/linoleic acid unilamellar vesicles (LUVs) (LP-LUV test); and (c). UV-induced peroxidation of phosphatidylcholine multilamellar vesicles (UV-IP test). The in vivo antioxidant/radical scavenger activity was assessed by determining the ability of topically applied LECS to reduce UVB-induced skin erythema in healthy human volunteers. From the results obtained in in vitro and in vivo tests, LECS showed a significant antioxidant effect. Furthermore, by chromatographic fractionation and spectroscopic methods, we identified the major constituents of LECS, and particularly some flavonols (kaempferol and quercetin derivatives) and hydroxycinnamic acids (caffeic acid, ferulic acid, p-cumaric acid, and cinnamic acid).read more
Citations
More filters
Journal ArticleDOI
A review on the dietary flavonoid kaempferol.
José Manuel Calderón-Montaño,Estefanía Burgos-Morón,Concepción Pérez-Guerrero,Miguel López-Lázaro +3 more
TL;DR: The distribution of ka Kempferol in the plant kingdom and its pharmacological properties are reviewed and the pharmacokinetics and safety of kaempferol are analyzed to help understand the health benefits of kaEMPferol-containing plants and to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.
Journal ArticleDOI
Natural phenolics in the prevention of UV-induced skin damage. A review.
TL;DR: This review strives to summarize the findings of studies performed to date, regarding the photoprotective effects of plant phenolics on the skin damage induced by UV radiation.
Journal ArticleDOI
Photochemoprevention of skin cancer by botanical agents.
TL;DR: This review focuses on skin cancer photochemopreventive effects of selected botanical antioxidants, a wide range of which has been shown to prevent skin cancer in animal model systems.
Journal ArticleDOI
Natural products as photoprotection
Nisakorn Saewan,Ampa Jimtaisong +1 more
TL;DR: A number of natural products derived from propolis, plants, algae, and lichens that have shown potential photoprotection properties against UV radiation exposure‐induced skin damage are summarized.
Journal ArticleDOI
The isolation and antioxidative effects of vitexin from Acer palmatum.
Jin-Hwa Kim,Bum Chun Lee,Jin Hui Kim,Gwan Sub Sim,Dong-Hwan Lee,Kyung Eun Lee,Yeo Pyo Yun,Hyeong Bae Pyo +7 more
TL;DR: The results show that oxidation of 5-(6-)chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate is inhibited by vitexin effectively and that viteXin has a potent free radical scavenging activity in UVB-irradiated HDFs.
References
More filters
Journal ArticleDOI
Dipalmitoylphosphatidylcholine/linoleic acid mixed unilamellar vesciles as model membranes for studies on novel free-radical scavengers
Francesco Castelli,Domenico Trombetta,Antonio Tomaino,Francesco Bonina,Giovanni Romeo,Nicola Uccella,Antonella Saija +6 more
TL;DR: Dipalmitoylphosphatidylcholine/linoleic acid-mixed LUVs were employed as model membranes to verify the inhibitory effect of tocopherol (an efficient representative antioxidant) against 2,2'-azobis(2-amidinopropane)hydrochloride-induced peroxidation (evaluated by monitoring conjugated diene accumulation).
Journal Article
In vivo evaluation of radical scavenger compounds in cosmetic formulations by means of skin reflectance spectrophotometry
F. Bonina,L. Montenegro +1 more
TL;DR: Tocopherol and tocophersyl acetate showed comparable activity but they were less effective that tocopheryl nicotinate and to copheryl succinate, while tocopherol and some of its esters with different lipophilicity showed less effective.
Journal ArticleDOI
Flavonol glycosides from aristeguietia discolor and their inhibitory activity on electrically-stimulated guinea pig ileum
Paola Saturnino,Anna Capasso,Carmela Saturnino,Giovanni De Martino,Nancy Lozano Reyes,Rita Patrizia Aquino +5 more
TL;DR: The structure of the new glycoside 1 was elucidated by spectral methods including 1D TOCSY and 2D DQF-COSY and some partially purified fractions and pure compounds were studied on the guinea-pig contractions in vitro.
Related Papers (5)
Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source.
Hypolipidemic activity of aqueous extract of Capparis spinosa L. in normal and diabetic rats
Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa.
Chhaya Gadgoli,Shri Hari Mishra +1 more