Open AccessJournal Article
In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L buds.
Francesco Bonina,Carmelo Puglia,Dario Ventura,Rita Patrizia Aquino,S Tortora,Antonia Sacchi,Antonella Saija,Antonio Tomaino,Maria Luisa Pellegrino,P de Caprariis +9 more
TLDR
From the results obtained in in vitro and in vivo tests, LECS showed a significant antioxidant effect and some flavonols (kaempferol and quercetin derivatives) and hydroxycinnamic acids (caffeic acid, ferulic acid, p-cumaric Acid, and cinnamic acid).Abstract:
The aim of the present study was to evaluate the in vitro antioxidant and in vivo photoprotective activities of a lyophilized extract of Capparis spinosa L. (LECS) obtained by methanolic extraction from the flowering buds of this plant. For the in vitro experiments, LECS was tested employing three different models: (a). bleaching of the stable 1,1-diphenyl-2-picrylhydrazyl radical (DPPH test); (b). peroxidation, induced by the water-soluble radical initiator 2,2'-azobis(2-amidinopropane) hydrochloride, of mixed dipalmitoylphosphatidylcholine/linoleic acid unilamellar vesicles (LUVs) (LP-LUV test); and (c). UV-induced peroxidation of phosphatidylcholine multilamellar vesicles (UV-IP test). The in vivo antioxidant/radical scavenger activity was assessed by determining the ability of topically applied LECS to reduce UVB-induced skin erythema in healthy human volunteers. From the results obtained in in vitro and in vivo tests, LECS showed a significant antioxidant effect. Furthermore, by chromatographic fractionation and spectroscopic methods, we identified the major constituents of LECS, and particularly some flavonols (kaempferol and quercetin derivatives) and hydroxycinnamic acids (caffeic acid, ferulic acid, p-cumaric acid, and cinnamic acid).read more
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The caper (Capparis L.): ethnopharmacology, phytochemical and pharmacological properties.
TL;DR: The presented review summarizes information concerning the morphology, ethnopharmacology, phytochemistry, and biological activities of caper plants.
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Protective effect of Capparis spinosa on chondrocytes.
Annamaria Panico,Venera Cardile,F. Garufi,Carmelo Puglia,Francesco Bonina,Giuseppe Ronsisvalle +5 more
TL;DR: It is observed that LECS was able to counteract the harmful effects induced by IL-1beta, and appeared to be greater than that elicited by indomethacin, which is usually employed in joint diseases.
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Less‐known botanical cosmeceuticals
TL;DR: The focus in this discussion will be on a select group of botanical compounds that have been used for dermatologic purposes or show promise for such applications, including rosemary, polypodium leucotomos, propolis, oatmeal, olive oil, grape seed extract, lavender, mushrooms, and coffeeberry.
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Bioactive components of caper (Capparis spinosa L.) from sicily and antioxidant effects in a red meat simulated gastric digestion
TL;DR: The findings encourage the use of caper with foods that contribute oxidizable lipids in view of the association between dietary oxidized lipids and risk of oxidative stress-based diseases.
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Antiviral and immunomodulatory effect of a lyophilized extract of Capparis spinosa L. buds.
Adriana Arena,Giuseppe Bisignano,Bernadette Pavone,Antonio Tomaino,Francesco Bonina,Antonella Saija,Mariateresa Cristani,Manuela D'Arrigo,Domenico Trombetta +8 more
TL;DR: It is shown that CAP treatment interferes with HSV‐2 replication in PBMCs inhibiting the extracellular virus release upregulating their production of IL‐12, IFN‐γ and TNF‐α, and should thus be successfully employed for treatment of HSV-2 infections in immunocompromised hosts.
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