Open AccessJournal Article
In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L buds.
Francesco Bonina,Carmelo Puglia,Dario Ventura,Rita Patrizia Aquino,S Tortora,Antonia Sacchi,Antonella Saija,Antonio Tomaino,Maria Luisa Pellegrino,P de Caprariis +9 more
TLDR
From the results obtained in in vitro and in vivo tests, LECS showed a significant antioxidant effect and some flavonols (kaempferol and quercetin derivatives) and hydroxycinnamic acids (caffeic acid, ferulic acid, p-cumaric Acid, and cinnamic acid).Abstract:
The aim of the present study was to evaluate the in vitro antioxidant and in vivo photoprotective activities of a lyophilized extract of Capparis spinosa L. (LECS) obtained by methanolic extraction from the flowering buds of this plant. For the in vitro experiments, LECS was tested employing three different models: (a). bleaching of the stable 1,1-diphenyl-2-picrylhydrazyl radical (DPPH test); (b). peroxidation, induced by the water-soluble radical initiator 2,2'-azobis(2-amidinopropane) hydrochloride, of mixed dipalmitoylphosphatidylcholine/linoleic acid unilamellar vesicles (LUVs) (LP-LUV test); and (c). UV-induced peroxidation of phosphatidylcholine multilamellar vesicles (UV-IP test). The in vivo antioxidant/radical scavenger activity was assessed by determining the ability of topically applied LECS to reduce UVB-induced skin erythema in healthy human volunteers. From the results obtained in in vitro and in vivo tests, LECS showed a significant antioxidant effect. Furthermore, by chromatographic fractionation and spectroscopic methods, we identified the major constituents of LECS, and particularly some flavonols (kaempferol and quercetin derivatives) and hydroxycinnamic acids (caffeic acid, ferulic acid, p-cumaric acid, and cinnamic acid).read more
Citations
More filters
Journal ArticleDOI
In Vitro Antioxidant and In Vivo Photoprotective Effects of an Association of Bioflavonoids with Liposoluble Vitamins
Patrícia M. B. G. Maia Campos,Mirela D. Gianeti,Alexandre Kanashiro,Yara Maria Lucisano-Valim,Lorena Rigo Gaspar +4 more
TL;DR: The results showed that bioflavonoids had in vitro antioxidant properties and also that when they were associated with vitamins their antioxidant activity was more pronounced, which suggests its use in antiaging and photoprotective products.
Journal ArticleDOI
Pharmacological Effects of Capparis spinosa L.
Seyed Fazel Nabavi,Filippo Maggi,Maria Daglia,Solomon Habtemariam,Luca Rastrelli,Seyed Mohammad Nabavi +5 more
TL;DR: Different health promotion activities, as well as tremendous diversity of active constituents, make C. spinosa a good candidate for discovering new drugs, however these findings are still in its infancy and future experimental and clinical studies are needed.
Journal ArticleDOI
In vitro percutaneous absorption studies and in vivo evaluation of anti-inflammatory activity of essential fatty acids (EFA) from fish oil extracts.
TL;DR: The in vitro experiments revealed interesting fluxes of these compounds from sardine extract through the stratum corneum/epidermis membranes and an appreciable anti-inflammatory activity against UVB-induced erythema in human volunteers was also observed.
Journal ArticleDOI
Phenolic components, antioxidant activity, and mineral analysis of Capparis spinosa L
TL;DR: In this paper, the authors analyzed a number of individual phenolic compounds and investigated in vitro biological activities of Capparis spinosa L. They found that C. spinosa exhibited strong antioxidant activity and contained high levels of antioxidant compounds.
Journal ArticleDOI
Genotoxic and Antimutagenic Effects of Capparis spinosa L. on the Allium cepa L. Root Tip Meristem Cells
TL;DR: It is suggested that CS buds aqueous extract is non-genotoxic and has antimutagenic potential against EMS induced chromosomal aberrations in A. cepa root meristem cells and the antimutogenic potential of CS flower buds extract is effective at 30 g/L concentration.
References
More filters
Journal ArticleDOI
Antioxidant properties of phenolic compounds
TL;DR: It is now possible to establish the antioxidant activities of plant-derived flavonoids in the aqueous and lipophilic phases, and to assess the extent to which the total antioxidant potentials of wine and tea can be accounted for by the activities of individual polyphenols.
Book
The Flavonoids: Advances in Research since 1980
TL;DR: In this paper, the authors discuss the distribution and evolution of the Flavonoids in the Lower Plants and its evolution in the Dicotyledons of the world's plants.
Book
The Flavonoids Advances in Research Since 1986
TL;DR: The anthocyanins. 1H NMR spectroscopy of flavonoids and their glycosides as discussed by the authors, and the major and minor flavonoid glycoside.
Structural aspects of antioxidant activity of flavonoids.
TL;DR: It can be concluded that Ep/2 values and iron chelating activity can almost completely describe the LPO inhibiting behaviour of the flavonoids.
Journal ArticleDOI
Structural aspects of antioxidant activity of flavonoids.
S.A.B.E. van Acker,D.-J. Van Den Berg,M. N. J. L. Tromp,D. H. Griffioen,W.P. van Bennekom,W.J.F. van der Vijgh,Aalt Bast +6 more
TL;DR: In this article, a large group of flavonoids from all major structural subclasses were tested on their ability to inhibit doxorubicin (enzymatically)-induced microsomal lipid peroxidation (LPO) and to chelate Fe2+.
Related Papers (5)
Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source.
Hypolipidemic activity of aqueous extract of Capparis spinosa L. in normal and diabetic rats
Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa.
Chhaya Gadgoli,Shri Hari Mishra +1 more