Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
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TLDR
Cells and mice that are deficient for the presumed DNA mismatch repair (MMR) gene Msh2 have lost mismatch binding and have acquired microsatellite instability, a mutator phenotype, and tolerance to methylating agents, suggesting that Msh1 is involved in safeguarding the genome from promiscuous recombination.About:
This article is published in Cell.The article was published on 1995-07-28 and is currently open access. It has received 813 citations till now. The article focuses on the topics: MSH2 & DNA mismatch repair.read more
Citations
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Journal ArticleDOI
Rates of Spontaneous Mutation
TL;DR: It is now possible to specify some of the evolutionary forces that shape these diverse mutation rates in broad groups of organisms.
Journal ArticleDOI
Microsatellite Instability in Colorectal Cancer
C. Richard Boland,Ajay Goel +1 more
TL;DR: Colorectal tumors with MSI have distinctive features, including a tendency to arise in the proximal colon, lymphocytic infiltrate, and a poorly differentiated, mucinous or signet ring appearance, and do not have the same response to chemotherapeutics.
Journal ArticleDOI
The multifaceted mismatch-repair system
TL;DR: This article reviews the current understanding of this multifaceted DNA-repair system in human cells and investigates how MMR status affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes.
Journal ArticleDOI
Brca1 controls homology-directed DNA repair.
TL;DR: A caretaker role for BRCA1 is demonstrated in preserving genomic integrity by promoting homologous recombination and limiting mutagenic nonhomologous repair processes.
Journal ArticleDOI
Mechanisms and functions of DNA mismatch repair
TL;DR: Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including hereditary non-polyposis colorectal cancer, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
References
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Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
Richard Fishel,Mary Kay Lescoe,M.R.S. Rao,Neal G. Copeland,Nancy A. Jenkins,Judy Garber,Michael F. Kane,Richard D. Kolodner +7 more
TL;DR: Data and reports indicating that S. cerevisiae msh2 mutations cause an instability of dinucleotide repeats like those associated with H NPCC suggest that hMSH2 is the HNPCC gene.
Journal ArticleDOI
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
Fredrick S. Leach,Nicholas C. Nicolaides,Nickolas Papadopoulos,Bo Liu,Jin Jen,Ramon Parsons,Päivi Peltomäki,Pertti Sistonen,Lauri A. Aaltonen,Minna Nyström-Lahti,Xin Yuan Guan,Ji Zhang,Paul S. Meltzer,Jing Wei Yu,Fa Ten Kao,David J. Chen,Karen M. Cerosaletti,R. E. Keith Fournier,Sean Todd,Tracey B. Lewis,Robin J. Leach,Susan L. Naylor,Jean Weissenbach,Jukka-Pekka Mecklin,Heikki Järvinen,Gloria M. Petersen,Stanley R. Hamilton,Jane Green,Jeremy R. Jass,Patrice Watson,Henry T. Lynch,Jeffrey M. Trent,Albert de la Chapelle,Kenneth W. Kinzler,Bert Vogelstein +34 more
TL;DR: Somatic as well as germline mutations of the gene were identified in RER+ tumor cells, and this mutS homolog is likely to be responsible for HNPCC.
Journal ArticleDOI
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer
C.E. Bronner,Sean M. Baker,Paul T. Morrison,Graham Warren,L.G. Smith,Lescoe Mk,Michael F. Kane,Earabino C,Lipford J,Annika Lindblom +9 more
TL;DR: It is reported that a human gene encoding a protein, hMLHl (human MutL homologue), homologous to the bacterial DNA mismatch repair protein MutL, is located on human chromosome 3p21.3-23.
Journal ArticleDOI
Mutation of a mutL homolog in hereditary colon cancer
Nickolas Papadopoulos,Nicholas C. Nicolaides,Ying Fei Wei,Steven M. Ruben,Kenneth C. Carter,Craig A. Rosen,William A. Haseltine,Robert D. Fleischmann,Claire M. Fraser,Mark Raymond Adams,J. Craig Venter,Stanley R. Hamilton,Gloria M. Petersen,Patrice Watson,Henry T. Lynch,Päivi Peltomäki,Jukka-Pekka Mecklin,Albert de la Chapelle,Kenneth W. Kinzler,Bert Vogelstein +19 more
TL;DR: A search of a large database of expressed sequence tags derived from random complementary DNA clones revealed three additional human mismatch repair genes, all related to the bacterial mutL gene, demonstrating that this gene is responsible for HNPCC.
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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
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