Increased fibroblast accumulation in the equine heart following persistent atrial fibrillation.
Arnela Saljic,Merle Friederike Fenner,Joris Winters,Mette Flethøj,Caroline Eggert Eggertsen,Helena Carstensen,Sarah Dalgas Nissen,Eva Melis Hesselkilde,Arne van Hunnik,Ulrich Schotten,Ulrik Svane Sørensen,Thomas Jespersen,Sander Verheule,Rikke Buhl +13 more
TLDR
In this paper, an equine model of persistent atrial fibrillation was used to characterize structural changes and the role of fibroblasts in the development of an arrhythmogenic substrate for AF.About:
This article is published in IJC Heart & Vasculature.The article was published on 2021-08-01 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Atrial fibrillation.read more
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Fibrotic Remodeling during Persistent Atrial Fibrillation: In Silico Investigation of the Role of Calcium for Human Atrial Myofibroblast Electrophysiology
TL;DR: In this paper, the authors extended a biophysical myofibroblast model with Ca2+ handling components and studied the effect on cellular and tissue electrophysiology using genetic algorithms.
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Paroxysmal Atrial Fibrillation in Horses: Pathophysiology, Diagnostics and Clinical Aspects
TL;DR: The potential to adapt human cardiac monitoring systems and computational ECG analysis is of interest and may benefit future diagnostic tools in equine medicine.
Journal ArticleDOI
Cartilaginous Intrusion of the Atrioventricular Node in a Quarter Horse with a High Burden of Second-Degree AV Block and Collapse: A Case Report
Sarah Dalgas Nissen,Arnela Saljic,Sofie T. Kjeldsen,Thomas Jespersen,Charlotte Hopster-Iversen,Rikke Buhl +5 more
TL;DR: An eight-year-old Quarter horse with a high burden of second-degree AV blocks and multiple collapses was presented and the heart inspected, finding the aortic root was severely cartilaginous and appeared to penetrate the AV node, especially in the His bundle region, possibly explaining the hampered AV conduction.
References
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Paulus Kirchhof,Stefano Benussi,Dipak Kotecha,Anders Ahlsson,Dan Atar,Barbara Casadei,Manuel Castellá,Hans-Christoph Diener,Hein Heidbuchel,Jeroen M.L. Hendriks,Gerhard Hindricks,Antonis S. Manolis,Jonas Oldgren,Bogdan A. Popescu,Ulrich Schotten,Bart P. Van Putte,Panagiotis Vardas,Stefan Agewall,John Camm,Gonzalo Barón Esquivias,Werner Budts,Scipione Carerj,Filip Casselman,Antonio Coca,Raffaele De Caterina,Spiridon Deftereos,Dobromir Dobrev,José M. Ferro,Gerasimos Filippatos,Donna Fitzsimons,Bulent Gorenek,Maxine Guenoun,Stefan H. Hohnloser,Philippe Kolh,Gregory Y.H. Lip,Athanasios J. Manolis,John J.V. McMurray,Piotr Ponikowski,Raphael Rosenhek,Frank Ruschitzka,Irina Savelieva,Sanjay Sharma,Piotr Suwalski,Juan Tamargo,Clare J Taylor,Isabelle C. Van Gelder,Adriaan A. Voors,Stephan Windecker,José Luis Zamorano,Katja Zeppenfeld +49 more
TL;DR: The Task Force for the management of atrial fibrillation of the European Society of Cardiology has been endorsed by the European Stroke Organisation (ESO).
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How cells read TGF-beta signals.
TL;DR: The TGF-β family of cytokines can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell.
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Electrical, contractile and structural remodeling during atrial fibrillation
TL;DR: Both AF itself and the underlying heart disease are responsible for the development of the arrhythmogenic substrate, and the role of structural remodeling in the progression of AF is still unclear.
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Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal
TL;DR: A translational overview on the biological basis of atrial remodeling and the proarrhythmic mechanisms involved in the fibrillation process is given.
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Cardiac fibroblast: the renaissance cell.
TL;DR: Insight is provided into the various properties of cardiac fibroblasts that helps illustrate their importance in maintaining proper cardiac function, as well as their critical role in the remodeling heart.