Influence of Imidazole-Dipeptides on Cognitive Status and Preservation in Elders: A Narrative Review.
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TLDR
In this paper, the results of human intervention studies using supplements of poultry-derived imidazole dipeptides, including anserine and carnosine, affecting the preservation of cognitive function in the elderly were discussed.Abstract:
The worldwide increase in the number of patients with dementia is becoming a growing problem, while Alzheimer's disease (AD), a primary neurodegenerative disorder, accounts for more than 70% of all dementia cases. Research on the prevention or reduction of AD occurrence through food ingredients has been widely conducted. In particular, histidine-containing dipeptides, also known as imidazole dipeptides derived from meat, have received much attention. Imidazole dipeptides are abundant in meats such as poultry, fish, and pork. As evidenced by data from recent human intervention trials conducted worldwide, daily supplementation of carnosine and anserine, which are both imidazole dipeptides, can improve memory loss in the elderly and reduce the risk of developing AD. This article also summarizes the latest researches on the biochemical properties of imidazole dipeptides and their effects on animal models associated with age-related cognitive decline. In this review, we focus on the results of human intervention studies using supplements of poultry-derived imidazole dipeptides, including anserine and carnosine, affecting the preservation of cognitive function in the elderly, and discuss how imidazole dipeptides act in the brain to prevent age-related cognitive decline and the onset of dementia.read more
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Effects of Dietary Food Components on Cognitive Functions in Older Adults.
TL;DR: In this article, a review summarizes previous reports on the biological process of cognitive decline in the elderly and the relationship between individual compounds in foods and cognitive function, as well as the role of individual components of food in cognitive function.
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Association between Micronutrient-Related Dietary Pattern and Cognitive Function among Persons 55 Years and Older in China: A Longitudinal Study
TL;DR: Wang et al. as discussed by the authors explored the association between dietary pattern and cognitive function in the Chinese population and found that higher adherence to the vegetable-pork diet is associated with better cognitive function among Chinese elders.
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Desorption electrospray ionization-mass spectrometry imaging of carnitine and imidazole dipeptides in pork chop tissues.
Hirofumi Enomoto,Nobuhiro Zaima +1 more
TL;DR: In this paper , the authors performed desorption electrospray ionization (DESI)-mass spectrometry imaging (MSI) of pork chop sections containing longissimus thoracis et lumborum muscle (loin), intermuscular fat tissue, transparent tissue, and spinalis muscle to investigate the distributions of carnitine and imidazole dipeptides.
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Critical Roles of Glial Neuroinflammation in Age-Related Memory Decline
TL;DR: In this paper , the authors found that chronic glial inflammatory reactions in the hippocampal formation are responsible for memory decline and that the suppression of the glial neuroinflammatory reactions can induce the prevention of memory decline.
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The crystal structure of 1-methyl-N-(1-methyl-1H-imidazole-2-carbonyl)-1H-imidazole-2-carboxamide, C10H11N5O2
TL;DR: In this paper , the orthorhombic Pca21 (no. 29), a = 22.6173(13) Å, b = 4.8730(3)Å, c = 9.9921(5) Ð, V = 1101.27(11) Á3, Z = 4, Rgt (F) = 0.0440, wRref (F 2) =0.0999, T = 200(2) K.
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