Journal ArticleDOI
Influence of nutrients and other dietary materials on cytochrome P-450 enzymes
Reads0
Chats0
TLDR
The cytochrome P-450 (P-450) enzymes are collectively responsible for the bulk of oxidation of xenobiotic chemicals, including drugs, pesticides, and carcinogens, which can result in increased or decreased toxicity, depending on the situation.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 1995-03-01. It has received 113 citations till now. The article focuses on the topics: Butylated hydroxytoluene & Xenobiotic.read more
Citations
More filters
Journal ArticleDOI
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.
TL;DR: An overview is presented on the molecular aspects of toxicity due to paracetamol (acetaminophen) and structural analogues, with emphasis on four main topics, that is, bioactivation, detoxication, chemoprevention, and chemoprotection.
Journal ArticleDOI
Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial
Alan P. Venook,Donna Niedzwiecki,Heinz-Josef Lenz,Federico Innocenti,Briant Fruth,Jeffrey A. Meyerhardt,Deborah Schrag,Claire Greene,Bert H. O'Neil,James N. Atkins,Scott R. Berry,Blase N. Polite,Eileen M. O'Reilly,Richard M. Goldberg,Howard S. Hochster,Richard L. Schilsky,Monica M. Bertagnolli,Anthony B. El-Khoueiry,Peter Watson,Al B. Benson,Daniel Mulkerin,Robert J. Mayer,Charles D. Blanke +22 more
TL;DR: Among patients with KRAS wt untreated advanced or metastatic colorectal cancer, there was no significant difference in overall survival between the addition of cetuximab vs bevacizumab to chemotherapy as initial biologic treatment.
Journal ArticleDOI
Role of plant polyphenols in genomic stability.
TL;DR: A small number of adequately controlled human intervention studies suggest that some, but not allpolyphenol extracts or high polyphenol diets may lead to transitory changes in the antioxidative capacity of plasma in humans, but none of these studies have adequately considered long-term effects on DNA or the chromosome.
Journal ArticleDOI
Linking herbivore experience, varied diets, and plant biochemical diversity
TL;DR: D diets and habitats that allow animals to select among alternatives enable individuals to better meet needs for nutrients and to better cope with toxins, and feeding and grazing practices that allow producers to capitalize on the individuality of animals are likely to improve performance of the herd by enabling the uniqueness of individuals to become manifest.
Journal ArticleDOI
Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes.
TL;DR: Despite the limitations of many currently available probes, with continued research, phenotyping will become an even more valuable research and clinical resource.
Related Papers (5)
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more