Inherited haemoglobin disorders: an increasing global health problem.
TLDR
It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.Abstract:
Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin, thousands of infants and children with these diseases are dying through lack of appropriate medical care. This problem will undoubtedly increase over the next 20 years because, as the result of a reduction in childhood mortality due to infection and malnutrition, more babies with haemoglobin disorders will survive to present for treatment. Although WHO and various voluntary agencies have tried to disseminate information about these diseases, they are rarely mentioned as being sufficiently important to be included in setting health care priorities for the future. It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.read more
Citations
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Molecular heterogeneity of β‐thalassemia variants in the Eastern region of Morocco
Ihab Belmokhtar,Saida Lhousni,A. Ghanam,Zaina Sidqi,Meryem Ouarzane,Majida Charif,Mohammed Bellaoui,Redouane Boulouiz,Noufissa Benajiba +8 more
TL;DR: The molecular profile of β‐thalassemia in the Eastern region of Morocco is presented for the first time, and it is shown that each ethnic group has its own mutation spectrum.
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A 10 month old girl with fever and cough
TL;DR: A 10 month old baby girl, hailing from the Cumilla (a city in the Chattogram Division), Bangladesh was brought to the Department of Hematology, Armed Forces Institute of Pathology, Dhaka Cantonment, Dh Bangladesh with the complaints of fever and cough for the last seven days.
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Silent cerebral infarct in sickle cell anemia patients of southern Turkey
Ezgi Nafile Sayman,Göksel Leblebisatan,Serife Leblebisatan,Kenan Bicakci,Yurdanur Kilinç,Adnan Barutçu +5 more
TL;DR: The presence of homozygote HbSS/Sβ0 genotype, high MCV, and HbS are risk factors for SCI, and SCI is not uncommon among SCA patients in Turkey.
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Xmn I polymorphism in Egyptian patients with β-thalassemia major and its correlation with the HbF level
TL;DR: The study found that the presence of the XmnI polymorphism influences HbF concentration and ameliorate the clinical severity of the disease.
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Nature and severity of dental malocclusion in children suffering from transfusion-dependent (-thalassemia major
TL;DR: A cross-sectional study was conducted on 200 transfusion-dependent children diagnosed with homozygous β-thalassemia and 200 healthy school children aged 11-17 years.
References
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