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Open AccessJournal ArticleDOI

Inherited haemoglobin disorders: an increasing global health problem.

TLDR
It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.
Abstract
Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin, thousands of infants and children with these diseases are dying through lack of appropriate medical care. This problem will undoubtedly increase over the next 20 years because, as the result of a reduction in childhood mortality due to infection and malnutrition, more babies with haemoglobin disorders will survive to present for treatment. Although WHO and various voluntary agencies have tried to disseminate information about these diseases, they are rarely mentioned as being sufficiently important to be included in setting health care priorities for the future. It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.

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Journal ArticleDOI

Zunahme genetisch determinierter Anämien durch Migration in Deutschland

B. Zur
- 22 Feb 2016 - 
TL;DR: In this paper, the Pravalenzen von genetisch determinierten Anamien in den ursprunglichen endemiegebieten zusammengestellt were verglichen.
Book ChapterDOI

Evolutionary Medicine, Immunity, and Infectious Disease

TL;DR: In this paper, the authors provide an introduction to evolutionary medicine with the specific purpose of better understanding human-pathogen coevolution and the development of human immune responses, as well as the genetic and ecological sources of variation in these responses.
Journal ArticleDOI

Molecular analysis of hemoglobinopathies in a large ethnic Hakka population in southern China.

Pingsen Zhao, +2 more
- 01 Nov 2018 - 
TL;DR: This study provided the insight into prevalence and molecular characterization of thalassemia in Hakka population and provided valuable references for the prevention and control of thAlzheimer's disease.
Journal ArticleDOI

Hereditary persistence of hemoglobin F is protective against red cell sickling. A case report and brief review

TL;DR: A case of SCD is described, in which a patient with high HbF level presented at a very late age (27 years old), and it is presumed the patient's inherently elevated HfF levels were able to compensate for the hypoxic episodes associated with SCD.
Journal ArticleDOI

Prenatal and post-natal screening of β-thalassemia and hemoglobin E genes in Thailand using denaturing high performance liquid chromatography

TL;DR: The DHPLC assay developed should prove useful for rapid screening of known and unknown β-thalassemia mutations during carrier screening and pre-natal diagnosis which would facilitate an ongoing prevention and control program of thalassemia.
References
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Journal ArticleDOI

Sickle cell disease

TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.

World development report 1993 : investing in health

TL;DR: This report examines the controversial questions surrounding health care and health policy and advocates a threefold approach to health policy for governments in developing countries and in the formerly socialist countries, based in large part on innovative research.
Journal ArticleDOI

Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia

TL;DR: Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful crises per year and Maximal tolerated doses of hydroxyurea may not be necessary to achieve a therapeutic effect.
Journal ArticleDOI

Pathogenesis and Treatment of Sickle Cell Disease

TL;DR: A wealth of information is produced on the mechanisms by which a single base substitution in the gene encoding the human β-globin subunit, with the resulting replacement of β6 glutamic acid by valine, leads to the protean and devastating clinical manifestations of sickle cell disease.