Inherited haemoglobin disorders: an increasing global health problem.
TLDR
It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.Abstract:
Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin, thousands of infants and children with these diseases are dying through lack of appropriate medical care. This problem will undoubtedly increase over the next 20 years because, as the result of a reduction in childhood mortality due to infection and malnutrition, more babies with haemoglobin disorders will survive to present for treatment. Although WHO and various voluntary agencies have tried to disseminate information about these diseases, they are rarely mentioned as being sufficiently important to be included in setting health care priorities for the future. It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.read more
Citations
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'All her children are born that way': gendered experiences of stigma in families affected by sickle cell disorder in rural Kenya.
TL;DR: Mothers of children with SCD were particularly vulnerable to stigmatisation within families, with underlying structural influences that suggest these findings may apply to other similar settings in Africa, and have relevance for other genetic conditions.
Journal ArticleDOI
Comparison of the efficacy of wheat-based snacks fortified with ferrous sulfate, electrolytic iron, or hydrogen-reduced elemental iron: randomized, double-blind, controlled trial in Thai women
Michael B. Zimmermann,Pattanee Winichagoon,Sueppong Gowachirapant,Sonja Y. Hess,Mary Harrington,Visith Chavasit,Sean R. Lynch,Richard F. Hurrell +7 more
TL;DR: Ferrous sulfate, electrolytic iron, and hydrogen-reduced iron, fortified into wheat-based snacks, significantly improved iron status in Thai women with low iron stores and was compared to no fortification iron or 12 mg Fe/d for 6 d/wk for 35 wk.
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Sickle cell disease as a paradigm of immigration hematology: new challenges for hematologists in Europe.
TL;DR: For most hematologists such issues may seem far removed from everyday practice, however, as genetic diseases are increasingly recognized as a major global health problem, many as mentioned in this paper find it difficult to underestimate the implications of demographic change for world health.
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T‐type calcium channel blockade improves survival and cardiovascular function in thalassemic mice
Sirinart Kumfu,Siriporn C. Chattipakorn,Kroekkiat Chinda,Suthat Fucharoen,Nipon Chattipakorn +4 more
TL;DR: Iron‐overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia, and the role of TTCC as well as other transporters such as divalent metal transporter1 (DMT1) and L‐type calcium channels (LTCC) as possible portals for iron entry into the heart in in vivo thAlassemic mice under an iron‐ overload condition has not been investigated.
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Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.
Ambroise Wonkam,Valentina Josiane Ngo Bitoungui,A. A. Vorster,Raj Ramesar,Richard S. Cooper,Bamidele O. Tayo,Guillaume Lettre,Jeanne Ngogang +7 more
TL;DR: This study has confirmed the associations of SNPs in BCL11A and HBS1L-MYB and fetal haemoglobin in Cameroonian SCA patients; hematological indices and hospitalization rates were also associated with specific allelic variants.
References
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