scispace - formally typeset
Open AccessJournal ArticleDOI

Inherited haemoglobin disorders: an increasing global health problem.

TLDR
It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.
Abstract
Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin, thousands of infants and children with these diseases are dying through lack of appropriate medical care. This problem will undoubtedly increase over the next 20 years because, as the result of a reduction in childhood mortality due to infection and malnutrition, more babies with haemoglobin disorders will survive to present for treatment. Although WHO and various voluntary agencies have tried to disseminate information about these diseases, they are rarely mentioned as being sufficiently important to be included in setting health care priorities for the future. It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.

read more

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI

Decision‐tree‐based methods for differential diagnosis of β‐thalassemia trait from iron deficiency anemia

TL;DR: This study is the first application of tree‐based methods for differential diagnosis of βTT from IDA and Classification Rule with Unbiased Interaction Selection and Estimation revealed more precise classification.
Book ChapterDOI

Infectious Disease and Host–Pathogen Evolution: J. B. S. Haldane and the Malaria Hypothesis

TL;DR: The origins of this hypothesis are examined, how it has stood the test of time, and the broader field of research which it has spawned are summarized, which attempts to understand the genetic basis of variability in individual susceptibility to infection in general.
Journal ArticleDOI

Variable genotype-phenotype correlations in patients with a rare nondeletional α-thalassemia; Hb Pak Num Po (HBA1: c.396_397insT).

TL;DR: The identification of 4 additional patients with Hb PNP with a broader genotype/phenotype spectrum are described and an overview of clinical management approaches including stem-cell transplantation is provided.
Journal ArticleDOI

Prevalence of Congenital Hemolytic Disorders in Denmark, 2000-2016

TL;DR: The prevalence of congenital RBC disorders in Denmark is increasing and the hemoglobinopathy traits now have prevalences as high as hereditary spherocytosis, emphasizing that inborn hemoglobin disorders are a public health concern, even in some formerly low prevalence countries.
Journal ArticleDOI

Analysis of genotype distribution of thalassemia and G6PD deficiency among Hakka population in Meizhou city of Guangdong Province

TL;DR: The aim of the study was to explore genotype distribution thalassemia and G6PD deficiency in Meizhou city, China.
References
More filters
Journal ArticleDOI

Sickle cell disease

TL;DR: New strategies for specific therapy, including expanded use of chronic transfusions, bone marrow transplantation, and hydroxyurea, now offer hope for prevention of many or all of the hemolytic and vaso-occlusive manifestations of sickle cell disease.

World development report 1993 : investing in health

TL;DR: This report examines the controversial questions surrounding health care and health policy and advocates a threefold approach to health policy for governments in developing countries and in the formerly socialist countries, based in large part on innovative research.
Journal ArticleDOI

Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia

TL;DR: Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful crises per year and Maximal tolerated doses of hydroxyurea may not be necessary to achieve a therapeutic effect.
Journal ArticleDOI

Pathogenesis and Treatment of Sickle Cell Disease

TL;DR: A wealth of information is produced on the mechanisms by which a single base substitution in the gene encoding the human β-globin subunit, with the resulting replacement of β6 glutamic acid by valine, leads to the protean and devastating clinical manifestations of sickle cell disease.