Inherited haemoglobin disorders: an increasing global health problem.
TLDR
It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.Abstract:
Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin, thousands of infants and children with these diseases are dying through lack of appropriate medical care. This problem will undoubtedly increase over the next 20 years because, as the result of a reduction in childhood mortality due to infection and malnutrition, more babies with haemoglobin disorders will survive to present for treatment. Although WHO and various voluntary agencies have tried to disseminate information about these diseases, they are rarely mentioned as being sufficiently important to be included in setting health care priorities for the future. It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.read more
Citations
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Prenatal Diagnosis of Hemoglobinopathies in Hacettepe University, Turkey
M. Sinan Beksaç,Fatma Gumruk,Aytemiz Gurgey,Nur Çakar,Sezcan Mumusoglu,Özgür Özyüncü,Cigdem Altay +6 more
TL;DR: The results of the study showed that β gene mutations in hemoglobinopathies have a very broad spectrum and the termination of 261 affected fetuses provided both psychological and economic relief for the parents and was economically beneficial for the country in the long term.
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Manifestations of HbSE sickle cell disease: a systematic review.
Ibrahim Khamees,Fateen Ata,Hassan Choudry,Ashraf T Soliman,Vincenzo De Sanctis,Mohamed A. Yassin +5 more
TL;DR: In this paper, the authors performed a systematic review according to the PRISMA guidelines using PubMed, SCOPUS, and Google Scholar databases, and synthesized data on demographics, manifestations, and management of HBSE disease.
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Impaired Collateral Vessel Formation in Sickle Cell Disease.
Derick Okwan-Duodu,Laura Hansen,Giji Joseph,Alicia N. Lyle,Daiana Weiss,David R. Archer,W. Robert Taylor,W. Robert Taylor,W. Robert Taylor +8 more
TL;DR: Dysfunctional collateral vessel formation in SS mice after vascular injury is suggested and the role of neutrophil depletion or treatment with the antioxidant N-acetylcysteine reduced oxidative stress and improved functional collateral formation in the SS mice.
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The Prevalence and Spectrum of α-Thalassemia in Guizhou Province of South China
Sheng-Wen Huang,Yin Xu,Xing-Mei Liu,Man Zhou,Gui-Fang Li,Bang-Quan An,Li Su,Xian Wu,Jing Lin +8 more
TL;DR: The results of this study will be useful in genetic counseling and prenatal diagnosis of α-thal in Guizhou Province.
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Mechanisms of and obstacles to iron cardiomyopathy in thalassemia.
Ching-Tien Peng,Ching-Tien Peng,Jeng Sheng Chang,Kang Hsi Wu,Chang Hai Tsai,Chang Hai Tsai,Huan Sheng Lin +6 more
TL;DR: The mechanisms underlying the development of heart disease in thalassemia are reviewed and strategies for therapeutic intervention in TM patients with congestive heart failure are reviewed.
References
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