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Inherited haemoglobin disorders: an increasing global health problem.

TLDR
It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.
Abstract
Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin, thousands of infants and children with these diseases are dying through lack of appropriate medical care. This problem will undoubtedly increase over the next 20 years because, as the result of a reduction in childhood mortality due to infection and malnutrition, more babies with haemoglobin disorders will survive to present for treatment. Although WHO and various voluntary agencies have tried to disseminate information about these diseases, they are rarely mentioned as being sufficiently important to be included in setting health care priorities for the future. It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.

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Journal ArticleDOI

Global epidemiology of haemoglobin disorders and derived service indicators

TL;DR: To demonstrate a method for using genetic epidemiological data to assess the needs for equitable and cost-effective services for the treatment and prevention of haemoglobin disorders, online databases, reference resources, and published articles are obtained.
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How malaria has affected the human genome and what human genetics can teach us about malaria.

TL;DR: The challenge for the next decade is to build the global epidemiological infrastructure required for statistically robust genomewide association analysis, as a way of discovering novel mechanisms of protective immunity that can be used in the development of an effective malaria vaccine.
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Iron bioavailability and dietary reference values

TL;DR: It would be timely to develop a range of iron bioavailability factors based not only on diet composition but also on subject characteristics, such as iron status and prevalence of obesity.
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Anaemia in low-income and middle-income countries

TL;DR: Anaemia is disproportionately concentrated in low socioeconomic groups, and that maternal anaemia is strongly associated with child anaemia, and the epidemiology, clinical assessment, pathophysiology, and consequences of anaemia in low-income and middle-income countries are reviewed.
References
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Journal ArticleDOI

7 Sickle cell disease: clinical management

TL;DR: In this review emphasis is placed on four sets of major complications of these syndromes and their management; the first set pertains to the management of anaemia and its sequelae; the second set addresses painful syndrome both acute and chronic; the third set discusses infections; the fourth section deals with organ failure.
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The role of genomics in studying genetic susceptibility to infectious disease

TL;DR: Recent studies of the genetic factors that may modify susceptibility to infection in humans are focused on and some recent developments in microbial genetics that may play an important role in this interaction are touched on.

Prenatal Diagnosis and Screening of the Haemoglobinopathies.

TL;DR: The most important aspects of carrier detection procedures, genetic counselling, population screening and prenatal diagnosis of the thalassaemias and sickle cell anaemia, including beta-thalassaemia, are reviewed.
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5 Thalassaemia: clinical management

TL;DR: This review will focus on recent advances in the treatment of thalassaemia and briefly review the progress in experimental approaches to treatment of this disorder.
Journal Article

Hemoglobin E-beta thalassemia in Uttar Pradesh.

TL;DR: Establishment of antenatal diagnostic services is necessary in those parts of India where both HbE and beta thalassemia mutations are commonly seen.