Inherited haemoglobin disorders: an increasing global health problem.
TLDR
It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.Abstract:
Despite major advances in our understanding of the molecular pathology, pathophysiology, and control and management of the inherited disorders of haemoglobin, thousands of infants and children with these diseases are dying through lack of appropriate medical care. This problem will undoubtedly increase over the next 20 years because, as the result of a reduction in childhood mortality due to infection and malnutrition, more babies with haemoglobin disorders will survive to present for treatment. Although WHO and various voluntary agencies have tried to disseminate information about these diseases, they are rarely mentioned as being sufficiently important to be included in setting health care priorities for the future. It takes considerable time to establish expertise in developing programmes for the control and management of these conditions, and the lessons learned in developed countries will need to be transmitted to those countries in which they occur at a high frequency.read more
Citations
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Effectiveness of Workplace Nutrition Programs on Anemia Status among Female Readymade Garment Workers in Bangladesh: A Program Evaluation
Muttaquina Hossain,Ziaul Islam,Sabiha Sultana,Ahmed S. Rahman,Christine Hotz,Md. Ahshanul Haque,Christina Nyhus Dhillon,Rudaba Khondker,Lynnette M. Neufeld,Tahmeed Ahmed +9 more
TL;DR: Workplace nutrition programs can reduce anemia in female RMG workers, with the greatest benefits observed when both nutritionally enhanced lunches and IFA supplements are provided.
Journal ArticleDOI
Clinical impact of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations among sickle cell disease patients of Central India.
TL;DR: It is determined whether the presence of the factor prothrombin gene G20210A variant, factor V gene G1691A mutation (factor V Leiden), and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms may be risk factors for vascular complications in individuals with SCD.
Journal ArticleDOI
Facial features of patients with sickle cell anemia.
Naiara Gonçalves Fonseca Maia,Luís Antônio dos Santos,Ricardo D. Coletta,Patrícia Helena Costa Mendes,Paulo Rogério Ferreti Bonan,Leonardo Batista Maia,Hercílio Martelli Júnior +6 more
TL;DR: Most patients with SCA did not show compensatory maxillary expansion, which was determined by the prevalence of decreased maxillary length and by the absence of maxillary protrusion in 69% of the SCA patients evaluated.
Journal ArticleDOI
Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations.
Clare Samuelson,Stefan Radtke,Haiying Zhu,Mallory J Llewellyn,Emily Fields,Savannah Cook,Meei-Li W. Huang,Keith R. Jerome,Keith R. Jerome,Hans-Peter Kiem,Hans-Peter Kiem,Olivier Humbert +11 more
TL;DR: In this article, the authors investigated the application of a CRISPR/Cas9 multiplex genome editing approach, in which both the BCL11A erythroid enhancer and HBG promoter are disrupted within human hematopoietic stem cells.
Fisiopatologia da anemia falciforme
Janaina Martins Souza,Patrick Elan Lemos Rosa,Roberta Lemos Souza,Geane Freitas Pires Castro +3 more
TL;DR: O Brasil apresenta uma populacao com diferentes origens etnicas e com diversificados graus de miscigenacao, indicando that a presenca da anemia falciforme e decorrente da imigracao de individuos originarios principalmente do continente africano.
References
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