Journal ArticleDOI
Inhibition of lncRNA Gm15834 Attenuates Autophagy-Mediated Myocardial Hypertrophy via the miR-30b-3p/ULK1 Axis in Mice.
Chao Song,Hanping Qi,Yongsheng Liu,Yunping Chen,Pilong Shi,Shu Zhang,Jing Ren,Lixin Wang,Yonggang Cao,Hongli Sun +9 more
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TLDR
A novel regulatory axis encompassing lncRNA Gm15834/miR-30b-3p/ULK1/autophagy in cardiac hypertrophy is identified, which may provide a potential therapy target for cardiachypertrophy.About:
This article is published in Molecular Therapy.The article was published on 2021-03-03. It has received 17 citations till now. The article focuses on the topics: Autophagy & Small hairpin RNA.read more
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Neutrophil-like cell membrane-coated siRNA of lncRNA AABR07017145.1 therapy for cardiac hypertrophy via inhibiting ferroptosis of CMECs
TL;DR: In this article , a combination of in vivo and in vitro studies was conducted to identify a lncRNA AABR07017145.1, named as lnc RNA AAB for short, and revealed that lncRN AAB was upregulated in the hearts of cardiac hypertrophy rats as well as in the Ang II-induced CMECs.
Journal ArticleDOI
Neutrophil-like cell membrane-coated siRNA of lncRNA AABR07017145.1 therapy for cardiac hypertrophy via inhibiting ferroptosis of CMECs
Pilong Shi,Minghui Li,Chao Song,Hanping Qi,Lina Ba,Yonggang Cao,Meitian Zhang,Yawen Xie,Jing Ren,Jiabi Wu,Ping Ren,Hongli Sun +11 more
TL;DR: In this article, a combination of in vivo and in vitro studies was conducted to identify a lncRNA AABR07017145.1 named as lnc RNA AAB for short, and revealed that lncRN AAB was upregulated in the hearts of cardiac hypertrophy rat as well as in the Ang II-induced CMECs.
Journal ArticleDOI
Suppression of lncRNA <i>Gm47283</i> attenuates myocardial infarction via <i>miR-706</i>/ <i>Ptgs2</i>/ferroptosis axis
TL;DR: Wang et al. as discussed by the authors integrated bioinformatics and molecular biological experiments to identify the novel lncRNA transcripts and elucidated its regulatory mechanism in myocardial infarction.
Journal ArticleDOI
The whole transcriptome analysis and the circRNA-lncRNA network construction in arsenic trioxide-treated mice myocardium.
Yanan Jiang,Xiu-Qing Shen,Chaorun Dong,Fengnan Zhi,Yang Gao,C. Shi,Yuqiu Chao,Jincheng Xu,Desi Shang,Juan Xu,Baofeng Yang,Xia Li,Yunlong Bai +12 more
TL;DR: In this paper , the authors investigated the molecular basis of ATO-induced cardiotoxicity through whole transcriptome analysis using RNA sequencing technique, which revealed that aberrantly expressed genes may be enriched in the 'Wnt signaling pathway', 'Hippo signaling pathway' and 'Notch signaling pathway'.
Journal ArticleDOI
Reconnoitering the Role of Long-Noncoding RNAs in Hypertrophic Cardiomyopathy: A Descriptive Review
Syeda Kiran Shahzadi,N. Naidoo,Alawi A. Alsheikh-Ali,Alawi A. Alsheikh-Ali,Manfredi Rizzo,Ali A. Rizvi,Raul D. Santos,Yajnavalka Banerjee,Yajnavalka Banerjee +8 more
TL;DR: A review of the known regulatory and functional roles of long non-coding RNAs in hereditary cardiomyopathy can be found in this article, where the authors show that the enhanced calcium sensitivity of the myofilaments plays a key role in the pathophysiology of HCM.
References
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Journal ArticleDOI
Autophagy in the Pathogenesis of Disease
TL;DR: This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.
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Long non-coding RNAs: insights into functions
TL;DR: The rapidly advancing field of long ncRNAs is reviewed, describing their conservation, their organization in the genome and their roles in gene regulation, and the medical implications.
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Molecular Mechanisms of Long Noncoding RNAs
Kevin C. Wang,Howard Y. Chang +1 more
TL;DR: These archetypes of lncRNA function may be a useful framework to consider how lncRNAs acquire properties as biological signal transducers and hint at their possible origins in evolution.
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Autophagy: process and function
TL;DR: In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.
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Autophagy in Health and Disease: A Double-Edged Sword
TL;DR: Identifying the autophagy genes in yeast and finding orthologs in other organisms reveals the conservation of the mechanism in eukaryotes and allows the use of molecular genetics and biology in different model systems to study this process.