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Open AccessJournal ArticleDOI

Insidious reintroduction of wild poliovirus into Israel, 2013.

TLDR
Israel was certified as polio-free country in June 2002, but wild-type polio virus ₁ (WPV₁) was isolated initially from routine sewage samples collected between 7 and 13 April 2013 in two cities in the Southern district, and WPV-specific analysis of samples indicated WPV⁁ introduction into that area in early February 2013.
Abstract
Israel was certified as polio-free country in June 2002, along with the rest of the World Health Organization European Region. Some 11 years later, wild-type polio virus ₁ (WPV₁) was isolated initially from routine sewage samples collected between 7 and 13 April 2013 in two cities in the Southern district. WPV₁-specific analysis of samples indicated WPV₁ introduction into that area in early February 2013. National supplementary immunisation with oral polio vaccine has been ongoing since August 2013.

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Environmental Surveillance for Polioviruses in the Global Polio Eradication Initiative

TL;DR: The status of environmental surveillance used by the Global Polio Eradication Initiative is summarized, the rationale for ES is provided, examples of ES methods and findings are given, and how these data are used to achieve poliovirus eradication are summarized.
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Wastewater surveillance for population-wide Covid-19: The present and future.

TL;DR: An epidemiological tool developed and refined by environmental scientists over the last 20 years (Wastewater-Based Epidemiology — WBE) holds the potential as a key tool in containing and mitigating Covid-19 outbreaks while also minimizing domino effects such as unnecessarily long stay-at-home policies that stress humans and economies alike.
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Polio vaccination: past, present and future.

TL;DR: Although substantial effectiveness and safety data exist on the use and delivery of OPV and IPV, several new research initiatives are currently underway to fill specific knowledge gaps to inform future vaccination policies that would assure polio is eradicated and eradication is maintained.
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Epidemiology of the Silent Polio Outbreak in Rahat, Israel, Based on Modeling of Environmental Surveillance Data

TL;DR: A framework to convert quantitative polymerase chain reaction (qPCR) cycle threshold data into scaled WPV1 and OPV1 concentrations for inference within a deterministic, compartmental infectious disease transmission model is developed, generating insights into the epidemiology of the outbreak.
References
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Journal ArticleDOI

Confidence limits on phylogenies: an approach using the bootstrap.

TL;DR: The recently‐developed statistical method known as the “bootstrap” can be used to place confidence intervals on phylogenies and shows significant evidence for a group if it is defined by three or more characters.
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MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
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A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.

TL;DR: Some examples were worked out using reported globin sequences to show that synonymous substitutions occur at much higher rates than amino acid-altering substitutions in evolution.
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Electrostatics of nanosystems: Application to microtubules and the ribosome

TL;DR: The application of numerical methods are presented to enable the trivially parallel solution of the Poisson-Boltzmann equation for supramolecular structures that are orders of magnitude larger in size.
Journal ArticleDOI

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
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