Isolated effect of geometry on mitral valve function for in silico model development.
Andrew W. Siefert,Jean-Pierre Rabbah,Neelakantan Saikrishnan,Karyn S. Kunzelman,Ajit Prithivaraj Yoganathan +4 more
TLDR
A ground-truth data-set is generated by quantifying the effects of isolated mitral annular flattening, asymmetric annular dilatation, symmetric papillary muscle (PM) displacement and asymmetric PM displacement on leaflet coaptation, mitral regurgitation (MR) and anterior leaflet strain to improve MV computational models and provide a platform for the development of future surgical planning tools.Abstract:
Computational models for the heart's mitral valve (MV) exhibit several uncertainties that may be reduced by further developing these models using ground-truth data-sets. This study generated a ground-truth data-set by quantifying the effects of isolated mitral annular flattening, symmetric annular dilatation, symmetric papillary muscle (PM) displacement and asymmetric PM displacement on leaflet coaptation, mitral regurgitation (MR) and anterior leaflet strain. MVs were mounted in an in vitro left heart simulator and tested under pulsatile haemodynamics. Mitral leaflet coaptation length, coaptation depth, tenting area, MR volume, MR jet direction and anterior leaflet strain in the radial and circumferential directions were successfully quantified at increasing levels of geometric distortion. From these data, increase in the levels of isolated PM displacement resulted in the greatest mean change in coaptation depth (70% increase), tenting area (150% increase) and radial leaflet strain (37% increase) while a...read more
Citations
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Journal ArticleDOI
Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation.
Brian P. Baillargeon,Ivan F. Costa,Joseph R. Leach,Lik Chuan Lee,Martin Genet,Martin Genet,Arnaud Toutain,Jonathan F. Wenk,Manuel K. Rausch,Nuno Rebelo,Gabriel Acevedo-Bolton,Ellen Kuhl,Jose L. Navia,Julius M. Guccione +13 more
TL;DR: Improvements in the current study to the HCFS permit increasingly accurate study of myocardial mechanics and suggests that the first application of this simulator to abnormal human cardiac function suggests that the authors' novel annuloplasty ring with a sub-valvular element will correct ischemic mitral regurgitation.
Book ChapterDOI
The mitral valve
TL;DR: The most common manifestations of MVP are discussed, a condensed review of current pathophysiologic concepts are provided, and guidelines for diagnostic evaluation and further management are reviewed.
Journal ArticleDOI
Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement.
TL;DR: It is revealed that eccentric distortion of a TAVR stent can have a considerable impact on dynamic leaflet deformation, inducing deleterious bending of the leaflet and increasing commissures strains, which might expedite leaflet structural failure compared to leaflets in a circular deployed valve.
Journal ArticleDOI
Carpentier's Reconstructive Valve Surgery: From Valve Analysis to Valve Reconstruction, Alain Carpentier, David H. Adams, Farzan Filsoufi. Saunders, Maryland Heights, Missouri (2010), 368, illustrated, $199.00, ISBN: 978-0-7216-9168-8
Journal ArticleDOI
Finite Element Modeling of Mitral Valve Repair
Ashley E. Morgan,Joe Luis Pantoja,Jonathan W. Weinsaft,Eugene A. Grossi,Julius M. Guccione,Liang Ge,Mark B. Ratcliffe +6 more
TL;DR: An overview of relevant mitral valve diseases is presented, the evolution of FE models of surgical valve repair techniques are described, and Computational modeling through finite element (FE) analysis is described.
References
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Journal ArticleDOI
In vivo dynamic strains of the ovine anterior mitral valve leaflet
Manuel K. Rausch,Wolfgang Bothe,John-Peder Escobar Kvitting,Serdar Göktepe,D. Craig Miller,Ellen Kuhl +5 more
TL;DR: The in vivo strains of the anterior mitral valve leaflet are characterized and display significant temporal, regional, and directional variations with largest values inside the belly region and toward the free edge.
Journal ArticleDOI
Characterization of Mitral Valve Annular Dynamics in the Beating Heart
Manuel K. Rausch,Wolfgang Bothe,John-Peder Escobar Kvitting,Julia C. Swanson,Neil B. Ingels,Neil B. Ingels,D. Craig Miller,Ellen Kuhl +7 more
TL;DR: A novel mathematical model is introduced that allows us to identify temporal, regional, and inter-subject variations of clinical and mechanical metrics that characterize mitral annular form and function that can serve as a valuable tool to optimize both surgical and interventional approaches that aim at restoring mitral valve competence.
Journal Article
Mitral leaflet geometry perturbations with papillary muscle displacement and annular dilatation: an in-vitro study of ischemic mitral regurgitation.
TL;DR: Leaflet geometry during systole is affected by subvalvular structures and direct visualization of leaflet perturbation under these simulated pathological conditions may promote understanding of mechanisms present in ischemic MR.
Journal ArticleDOI
Semi-automated mitral valve morphometry and computational stress analysis using 3D ultrasound
Alison M. Pouch,Chun Xu,Paul A. Yushkevich,Arminder S. Jassar,Mathieu Vergnat,Joseph H. Gorman,Robert C. Gorman,Chandra M. Sehgal,Benjamin M. Jackson +8 more
TL;DR: The regional leaflet stress distributions predicted in normal and diseased (regurgitant) MVs are presented and semi-automated leaflet segmentation, 3D deformable modeling, and FEA modeling of the in vivo human MV is tenable and useful for evaluation of MV pathology.
Book ChapterDOI
The mitral valve
TL;DR: The most common manifestations of MVP are discussed, a condensed review of current pathophysiologic concepts are provided, and guidelines for diagnostic evaluation and further management are reviewed.