Isolated effect of geometry on mitral valve function for in silico model development.
Andrew W. Siefert,Jean-Pierre Rabbah,Neelakantan Saikrishnan,Karyn S. Kunzelman,Ajit Prithivaraj Yoganathan +4 more
TLDR
A ground-truth data-set is generated by quantifying the effects of isolated mitral annular flattening, asymmetric annular dilatation, symmetric papillary muscle (PM) displacement and asymmetric PM displacement on leaflet coaptation, mitral regurgitation (MR) and anterior leaflet strain to improve MV computational models and provide a platform for the development of future surgical planning tools.Abstract:
Computational models for the heart's mitral valve (MV) exhibit several uncertainties that may be reduced by further developing these models using ground-truth data-sets. This study generated a ground-truth data-set by quantifying the effects of isolated mitral annular flattening, symmetric annular dilatation, symmetric papillary muscle (PM) displacement and asymmetric PM displacement on leaflet coaptation, mitral regurgitation (MR) and anterior leaflet strain. MVs were mounted in an in vitro left heart simulator and tested under pulsatile haemodynamics. Mitral leaflet coaptation length, coaptation depth, tenting area, MR volume, MR jet direction and anterior leaflet strain in the radial and circumferential directions were successfully quantified at increasing levels of geometric distortion. From these data, increase in the levels of isolated PM displacement resulted in the greatest mean change in coaptation depth (70% increase), tenting area (150% increase) and radial leaflet strain (37% increase) while a...read more
Citations
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Journal ArticleDOI
Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation.
Brian P. Baillargeon,Ivan F. Costa,Joseph R. Leach,Lik Chuan Lee,Martin Genet,Martin Genet,Arnaud Toutain,Jonathan F. Wenk,Manuel K. Rausch,Nuno Rebelo,Gabriel Acevedo-Bolton,Ellen Kuhl,Jose L. Navia,Julius M. Guccione +13 more
TL;DR: Improvements in the current study to the HCFS permit increasingly accurate study of myocardial mechanics and suggests that the first application of this simulator to abnormal human cardiac function suggests that the authors' novel annuloplasty ring with a sub-valvular element will correct ischemic mitral regurgitation.
Book ChapterDOI
The mitral valve
TL;DR: The most common manifestations of MVP are discussed, a condensed review of current pathophysiologic concepts are provided, and guidelines for diagnostic evaluation and further management are reviewed.
Journal ArticleDOI
Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement.
TL;DR: It is revealed that eccentric distortion of a TAVR stent can have a considerable impact on dynamic leaflet deformation, inducing deleterious bending of the leaflet and increasing commissures strains, which might expedite leaflet structural failure compared to leaflets in a circular deployed valve.
Journal ArticleDOI
Carpentier's Reconstructive Valve Surgery: From Valve Analysis to Valve Reconstruction, Alain Carpentier, David H. Adams, Farzan Filsoufi. Saunders, Maryland Heights, Missouri (2010), 368, illustrated, $199.00, ISBN: 978-0-7216-9168-8
Journal ArticleDOI
Finite Element Modeling of Mitral Valve Repair
Ashley E. Morgan,Joe Luis Pantoja,Jonathan W. Weinsaft,Eugene A. Grossi,Julius M. Guccione,Liang Ge,Mark B. Ratcliffe +6 more
TL;DR: An overview of relevant mitral valve diseases is presented, the evolution of FE models of surgical valve repair techniques are described, and Computational modeling through finite element (FE) analysis is described.
References
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Journal ArticleDOI
In vitro dynamic strain behavior of the mitral valve posterior leaflet.
TL;DR: The investigation of MV dynamic strain behavior to quantify the dynamic strain on the central region of the posterior leaflet concluded that PM positions may influence the posterior strain in a different way as compared to the anterior leaflet.
Journal ArticleDOI
Chordal force distribution determines systolic mitral leaflet configuration and severity of functional mitral regurgitation
Sten Lyager Nielsen,Hans Nygaard,Arnold A. Fontaine,J. Michael Hasenkam,He S,Niels Trolle Andersen,Ajit P. Yoganathan +6 more
TL;DR: Altered chordal force distribution caused functional mitral regurgitation based on tented leaflet configuration as observed clinically.
Journal ArticleDOI
Stress-Strain Behavior of Mitral Valve Leaflets in the Beating Ovine Heart
Gaurav Krishnamurthy,Akinobu Itoh,Wolfgang Bothe,Julia C. Swanson,Ellen Kuhl,Matts Karlsson,D. Craig Miller,Neil B. Ingels,Neil B. Ingels +8 more
TL;DR: In inverse finite element (FE) analysis, the AML, in vivo, operates linearly over a physiologic range of pressures in the closed mitral valve, unlike isolated leaflets.
Journal ArticleDOI
Mitral valve annuloplasty: a quantitative clinical and mechanical comparison of different annuloplasty devices.
Manuel K. Rausch,Wolfgang Bothe,John-Peder Escobar Kvitting,Julia C. Swanson,D. Craig Miller,Ellen Kuhl +5 more
TL;DR: Heterogeneous strain and curvature profiles suggest the need for heterogeneous support, which may spawn more rational design of annuloplasty devices using design concepts of functionally graded materials.
Journal ArticleDOI
Ischemic Mitral Regurgitation: A Quantitative Three-Dimensional Echocardiographic Analysis
Mathieu Vergnat,Arminder S. Jassar,Benjamin M. Jackson,Liam P. Ryan,Thomas J. Eperjesi,Alison M. Pouch,Stuart J. Weiss,Albert T. Cheung,Michael A. Acker,Joseph H. Gorman,Robert C. Gorman +10 more
TL;DR: Application of custom analysis techniques to three-dimensional echocardiography images allows a quantitative and systematic analysis of the MV, and demonstrates the extreme variability in pathologic anatomy that occurs in patients with severe IMR.