Isolated effect of geometry on mitral valve function for in silico model development.
Andrew W. Siefert,Jean-Pierre Rabbah,Neelakantan Saikrishnan,Karyn S. Kunzelman,Ajit Prithivaraj Yoganathan +4 more
TLDR
A ground-truth data-set is generated by quantifying the effects of isolated mitral annular flattening, asymmetric annular dilatation, symmetric papillary muscle (PM) displacement and asymmetric PM displacement on leaflet coaptation, mitral regurgitation (MR) and anterior leaflet strain to improve MV computational models and provide a platform for the development of future surgical planning tools.Abstract:
Computational models for the heart's mitral valve (MV) exhibit several uncertainties that may be reduced by further developing these models using ground-truth data-sets. This study generated a ground-truth data-set by quantifying the effects of isolated mitral annular flattening, symmetric annular dilatation, symmetric papillary muscle (PM) displacement and asymmetric PM displacement on leaflet coaptation, mitral regurgitation (MR) and anterior leaflet strain. MVs were mounted in an in vitro left heart simulator and tested under pulsatile haemodynamics. Mitral leaflet coaptation length, coaptation depth, tenting area, MR volume, MR jet direction and anterior leaflet strain in the radial and circumferential directions were successfully quantified at increasing levels of geometric distortion. From these data, increase in the levels of isolated PM displacement resulted in the greatest mean change in coaptation depth (70% increase), tenting area (150% increase) and radial leaflet strain (37% increase) while a...read more
Citations
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Journal ArticleDOI
Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation.
Brian P. Baillargeon,Ivan F. Costa,Joseph R. Leach,Lik Chuan Lee,Martin Genet,Martin Genet,Arnaud Toutain,Jonathan F. Wenk,Manuel K. Rausch,Nuno Rebelo,Gabriel Acevedo-Bolton,Ellen Kuhl,Jose L. Navia,Julius M. Guccione +13 more
TL;DR: Improvements in the current study to the HCFS permit increasingly accurate study of myocardial mechanics and suggests that the first application of this simulator to abnormal human cardiac function suggests that the authors' novel annuloplasty ring with a sub-valvular element will correct ischemic mitral regurgitation.
Book ChapterDOI
The mitral valve
TL;DR: The most common manifestations of MVP are discussed, a condensed review of current pathophysiologic concepts are provided, and guidelines for diagnostic evaluation and further management are reviewed.
Journal ArticleDOI
Total ellipse of the heart valve: the impact of eccentric stent distortion on the regional dynamic deformation of pericardial tissue leaflets of a transcatheter aortic valve replacement.
TL;DR: It is revealed that eccentric distortion of a TAVR stent can have a considerable impact on dynamic leaflet deformation, inducing deleterious bending of the leaflet and increasing commissures strains, which might expedite leaflet structural failure compared to leaflets in a circular deployed valve.
Journal ArticleDOI
Carpentier's Reconstructive Valve Surgery: From Valve Analysis to Valve Reconstruction, Alain Carpentier, David H. Adams, Farzan Filsoufi. Saunders, Maryland Heights, Missouri (2010), 368, illustrated, $199.00, ISBN: 978-0-7216-9168-8
Journal ArticleDOI
Finite Element Modeling of Mitral Valve Repair
Ashley E. Morgan,Joe Luis Pantoja,Jonathan W. Weinsaft,Eugene A. Grossi,Julius M. Guccione,Liang Ge,Mark B. Ratcliffe +6 more
TL;DR: An overview of relevant mitral valve diseases is presented, the evolution of FE models of surgical valve repair techniques are described, and Computational modeling through finite element (FE) analysis is described.
References
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Journal ArticleDOI
Mitral valve surgery in low ejection fraction, severe ischemic mitral regurgitation patients: should we repair them all?
Jerry Braun,Robert J.M. Klautz +1 more
TL;DR: The remaining challenge for cardiologists and surgeons is how to integrate data from different imaging techniques that assess mitral valve geometry and left ventricular size, geometry, function and potential functional recovery in order to individualize and optimize the surgical approach to patients with chronic ischemic mitral regurgitation.
Journal ArticleDOI
Patient-Specific Mitral Valve Closure Prediction Using 3D Echocardiography
TL;DR: An approach to modeling the closure of the mitral valve using patient-specific anatomical information derived from 3D transesophageal echocardiography (TEE) with promising results, with prediction errors on par with 3D TEE resolution and with good potential for applications in pre-operative planning.
Proceedings Article
Mitral valve patient-specific finite element modeling from 3-D real time echocardiography: a potential new tool for surgical planning
Emiliano Votta,A. Arnoldi,Alice Invernizzi,Raffaele Ponzini,Federico Veronesi,Gloria Tamborini,Mauro Pepi,Francesco Alamanni,Alberto Redaelli,Enrico G. Caiani +9 more
TL;DR: This work integrated into a MV FEM the patient-specific information about leaflets, annulus and papillary muscles geometry and dynamics, obtained from real-time 3D echocardiography, into a finite element model, and reported results consistent with experimental findings from literature.
Journal ArticleDOI
Mitral repair for functional mitral regurgitation in idiopathic dilated cardiomyopathy: a good operation done well may help.
TL;DR: This issue described a very interesting retrospective series of 54 patients with idiopathic dilated cardiomyopathy who underwent mitral valve repair for severe functional mitral regurgitation, and found that the strongest predictor of a recurrent MR, following mitral repair was a residual large AP diameter.