Keratoconus Treatment Algorithm
Konstantinos Andreanos,Kate Hashemi,Myrsini Petrelli,Konstantinos Droutsas,Ilias Georgalas,George Kymionis +5 more
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TLDR
Current evidence for cornea cross-linking, intrastromal corneal ring segments, and combined treatments highlights their place in keratoconus management while new promising emerging therapies are being investigated.Abstract:
Keratoconus management has significantly changed over the last two decades. The advent of new interventions such as cornea cross-linking, intrastromal corneal ring segments, and combined treatments provide corneal clinicians a variety of treatment options for the visual rehabilitation of keratoconus patients. This review summarizes current evidence for these treatments and highlights their place in keratoconus management while new promising emerging therapies are being investigated.read more
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Long Term Comparison of Sequential vs. Same-Day Simultaneous Collagen Cross-Linking and Topography-Guided PRK for Treatment of Keratoconus
TL;DR: In this article, the safety and efficacy of corneal collagen cross-linking and topography-guided photorefractive keratectomy (PRK) using a different sequence and timing were evaluated in consecutive keratoconus cases.
Journal Article
Effects Of Ultraviolet-a And Riboflavin On The Interaction Of Collagen And Proteoglycans During Corneal Cross-linking
TL;DR: In this paper, a model reaction system using purified, non-glycosylated PG core proteins in solution in vitro has been compared with reactions inside an intact cornea, ex vivo, revealing effects of RFUVA on interactions between PGs and collagen cross-linking.
Journal ArticleDOI
Artificial intelligence for anterior segment diseases: Emerging applications in ophthalmology.
Darren Shu Jeng Ting,Valencia Hx Foo,Lily Wei Yun Yang,Josh Tjunrong Sia,Marcus Ang,Haotian Lin,James Chodosh,Jodhbir S. Mehta,Daniel Shu Wei Ting +8 more
TL;DR: An overview of AI applications to the anterior segment addressing keratoconus, infectious keratitis, refractive surgery, corneal transplant, adult and paediatric cataracts, angle-closure glaucoma and iris tumour is provided and important clinical considerations for adoption of AI technologies, potential integration with telemedicine and future directions are highlighted.
Conventional vs accelerated corneal collagen cross-linking in the treatment of keratoconus
TL;DR: In this article, the authors compared the effect of conventional corneal collagen cross-linking (CXL) with accelerated CXL in the treatment of keratoconus.
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Intraocular lens power calculation in keratoconus; A review of literature.
TL;DR: There are multiple sources of biometric error in KCN patients, hence IOL calculation methods may not be as efficient as expected in these eyes, and various methods of IOL power calculation optimization and recommendations may hold the key to improve surgical outcomes in keratoconic eyes.
References
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Journal ArticleDOI
Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.
TL;DR: Collagen crosslinking may be a new way for stopping the progression of keratectasia in patients with keratoconus and the need for penetrating keratoplasty might then be significantly reduced in keratconus.
Journal ArticleDOI
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk
Ganna Chornokur,Hui-Yi Lin,Jonathan Tyrer,Kate Lawrenson,Joe Dennis,Ernest K. Amankwah,Xiaotao Qu,Ya-Yu Tsai,Heather S.L. Jim,Zhihua Chen,Ann Y. Chen,Jennifer Permuth-Wey,Katja K.H. Aben,Hoda Anton-Culver,Natalia Antonenkova,Fiona Bruinsma,Elisa V. Bandera,Yukie Bean,Matthias W. Beckmann,Maria Bisogna,Line Bjørge,Natalia Bogdanova,Louise A. Brinton,Angela Brooks-Wilson,Clareann H. Bunker,Ralf Bützow,Ian G. Campbell,Karen Carty,Jenny Chang-Claude,Linda S. Cook,Daniel W. Cramer,Julie M. Cunningham,Cezary Cybulski,Agnieszka Dansonka-Mieszkowska,Andreas du Bois,Evelyn Despierre,Ed Dicks,Jennifer A. Doherty,Thilo Dörk,Matthias Dürst,Douglas F. Easton,Diana Eccles,Robert P. Edwards,Arif B. Ekici,Peter A. Fasching,Brooke L. Fridley,Yu-Tang Gao,Aleksandra Gentry-Maharaj,Graham G. Giles,Rosalind Glasspool,Marc T. Goodman,Jacek Gronwald,Patricia Harrington,Philipp Harter,Alexander Hein,Florian Heitz,Michelle A.T. Hildebrandt,Peter Hillemanns,Claus Høgdall,Estrid Høgdall,Satoyo Hosono,Anna Jakubowska,Allan Jensen,Bu-Tian Ji,Beth Y. Karlan,Linda E. Kelemen,Mellissa Kellar,Lambertus A. Kiemeney,Camilla Krakstad,Susanne K. Kjaer,Jolanta Kupryjanczyk,Diether Lambrechts,Sandrina Lambrechts,Nhu D. Le,Alice W. Lee,Shashi Lele,Arto Leminen,Jenny Lester,Douglas A. Levine,Dong Liang,Boon Kiong Lim,Jolanta Lissowska,Karen Lu,Jan Lubinski,Lene Lundvall,Leon F.A.G. Massuger,Keitaro Matsuo,Valerie McGuire,John R. McLaughlin,Iain A. McNeish,Usha Menon,Roger L. Milne,Francesmary Modugno,Kirsten B. Moysich,Roberta B. Ness,Heli Nevanlinna,Ursula Eilber,Kunle Odunsi,Sara H. Olson,Irene Orlow,Sandra Orsulic,Rachel Palmieri Weber,James Paul,Celeste Leigh Pearce,Tanja Pejovic,Liisa M. Pelttari,Malcolm C. Pike,Elizabeth M. Poole,Harvey A. Risch,Barry P. Rosen,Mary Anne Rossing,Joseph H. Rothstein,Anja Rudolph,Ingo B. Runnebaum,Iwona K. Rzepecka,Helga B. Salvesen,Eva S. Schernhammer,Ira Schwaab,Xiao-Ou Shu,Yurii B. Shvetsov,Nadeem Siddiqui,Weiva Sieh,Honglin Song,Melissa C. Southey,Beata Spiewankiewicz,Lara Sucheston,Soo-Hwang Teo,Kathryn L. Terry,Pamela J. Thompson,Lotte Ansgaard Thomsen,Ingvild L. Tangen,Shelley S. Tworoger,Anne M. van Altena,Robert A. Vierkant,Ignace Vergote,Christine Walsh,Shan Wang-Gohrke,Nicolas Wentzensen,Alice S. Whittemore,Kristine G. Wicklund,Lynne R. Wilkens,Anna H. Wu,Xifeng Wu,Yin Ling Woo,Hannah P. Yang,Wei Zheng,Argyrios Ziogas,Hanis Nazihah Hasmad,Andrew Berchuck,Edwin S. Iversen,Joellen M. Schildkraut,Susan J. Ramus,Ellen L. Goode,Alvaro N.A. Monteiro,Simon A. Gayther,Steven A. Narod,Paul D.P. Pharoah,Thomas A. Sellers,Catherine M. Phelan +158 more
TL;DR: Associations between inherited cellular transport gene variants and risk of EOC histologic subtypes are revealed on a large cohort of women.
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A 48-Year Clinical and Epidemiologic Study of Keratoconus
TL;DR: From 1935 through 1982, keratoconus was newly diagnosed in a total of 64 residents of Olmsted County, Minnesota; there were no significant trends in incidence rates over time; the overall average annual rate was 2.0 per 100,000 population.
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Big-bubble technique to bare Descemet's membrane in anterior lamellar keratoplasty.
TL;DR: A lamellar keratoplasty technique to bare Descemet's membrane in which air is injected to detach the central DesceMET's is described, which is faster, safer, and easier to perform than previous methods.
Journal ArticleDOI
Global consensus on keratoconus and ectatic diseases.
José Álvaro Pereira Gomes,Donald T.H. Tan,Christopher J. Rapuano,Michael W. Belin,Renato Ambrósio,José L. Güell,François Malecaze,Kohji Nishida,Virender S Sangwan +8 more
TL;DR: This project reached consensus of ophthalmology experts from around the world regarding keratoconus and ectatic diseases, focusing on their definition, concepts, clinical management, and surgical treatments, and provides an insight into the current worldwide treatment of these conditions.