Acute Kidney Injury Network: Report of an Initiative to Improve Outcomes in Acute Kidney Injury
Ravindra L. Mehta,John A. Kellum,Sudhir V. Shah,Bruce A. Molitoris,Claudio Ronco,David G. Warnock,Adeera Levin +6 more
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TLDR
The Acute Kidney Injury Network (AKI Network) as discussed by the authors is a multidisciplinary collaborative network focused on AKI, which was established to improve care for patients with or at risk for AKI.Abstract:
Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Having a uniform standard for diagnosing and classifying AKI would enhance our ability to manage these patients. Future clinical and translational research in AKI will require collaborative networks of investigators drawn from various disciplines, dissemination of information via multidisciplinary joint conferences and publications, and improved translation of knowledge from pre-clinical research. We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI. Members representing key societies in critical care and nephrology along with additional experts in adult and pediatric AKI participated in a two day conference in Amsterdam, The Netherlands, in September 2005 and were assigned to one of three workgroups. Each group's discussions formed the basis for draft recommendations that were later refined and improved during discussion with the larger group. Dissenting opinions were also noted. The final draft recommendations were circulated to all participants and subsequently agreed upon as the consensus recommendations for this report. Participating societies endorsed the recommendations and agreed to help disseminate the results. The term AKI is proposed to represent the entire spectrum of acute renal failure. Diagnostic criteria for AKI are proposed based on acute alterations in serum creatinine or urine output. A staging system for AKI which reflects quantitative changes in serum creatinine and urine output has been developed. We describe the formation of a multidisciplinary collaborative network focused on AKI. We have proposed uniform standards for diagnosing and classifying AKI which will need to be validated in future studies. The Acute Kidney Injury Network offers a mechanism for proceeding with efforts to improve patient outcomes.read more
Citations
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KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
Journal ArticleDOI
Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document.
A. Pieter Kappetein,Stuart J. Head,Philippe Généreux,Nicolo Piazza,Nicolas M. Van Mieghem,Eugene H. Blackstone,Thomas G. Brott,David J. Cohen,Donald E. Cutlip,Gerrit Anne van Es,Rebecca T. Hahn,Ajay J. Kirtane,Mitchell W. Krucoff,Susheel Kodali,Michael J. Mack,Roxana Mehran,Josep Rodés-Cabau,Pascal Vranckx,John G. Webb,Stephan Windecker,Patrick W. Serruys,Martin B. Leon +21 more
TL;DR: This VARC-2 document has provided further standardization of endpoint definitions for studies evaluating the use of TAVI, which will lead to improved comparability and interpretability of the study results, supplying an increasingly growing body of evidence with respect to TAVi and/or surgical aortic valve replacement.
Journal ArticleDOI
Updated Standardized Endpoint Definitions for Transcatheter Aortic Valve Implantation
A. Pieter Kappetein,Stuart J. Head,Philippe Généreux,Nicolo Piazza,Nicolas M. Van Mieghem,Eugene H. Blackstone,Thomas G. Brott,David Cohen,Donald E. Cutlip,Gerrit-Anne van Es,Rebecca T. Hahn,Ajay J. Kirtane,Mitchell W. Krucoff,Susheel Kodali,Michael J. Mack,Roxana Mehran,Josep Rodés-Cabau,Pascal Vranckx,John G. Webb,Stephan Windecker,Patrick W. Serruys,Martin B. Leon +21 more
TL;DR: This VARC-2 document has provided further standardization of endpoint definitions for studies evaluating the use of TAVI, which will lead to improved comparability and interpretability of the study results, supplying an increasingly growing body of evidence with respect to TAVi and/or surgical aortic valve replacement.
Journal ArticleDOI
Acute kidney injury
TL;DR: Evidence suggests that patients who have had acute kidney injury are at increased risk of subsequent chronic kidney disease, and new diagnostic techniques (eg, renal biomarkers) might help with early diagnosis.
Journal ArticleDOI
Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study
Eric Hoste,Eric Hoste,Eric Hoste,Sean M. Bagshaw,Rinaldo Bellomo,Cynthia M. Cely,Roos Colman,Dinna N. Cruz,Kyriakos Edipidis,Lui G. Forni,Charles D. Gomersall,Deepak Govil,Patrick M. Honore,Olivier Joannes-Boyau,Michael Joannidis,Anna-Maija Korhonen,Athina Lavrentieva,Ravindra L. Mehta,Paul M. Palevsky,Eric Roessler,Claudio Ronco,Shigehiko Uchino,Jorge A. Vazquez,Erick Vidal Andrade,Steve Webb,John A. Kellum +25 more
TL;DR: This is the first multinational cross-sectional study on the epidemiology of AKI in ICu patients using the complete KDIGO criteria and found that AKI occurred in more than half of ICU patients.
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RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis.
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